Interaction between the Renin-Angiotensin System and Enteric Neurotransmission Contributes to Colonic Dysmotility in the TNBS-Induced Model of Colitis.

Ferreira-Duarte, Mariana; Rodrigues-Pinto, Tiago; Sousa, Teresa; Faria, Miguel A; Rocha, Maria Sofia; Menezes-Pinto, Daniela; Esteves-Monteiro, Marisa; Magro, Fernando; Dias-Pereira, Patrícia; Duarte-Araújo, Margarida; Morato, Manuela

Ferreira-Duarte, Mariana; Rodrigues-Pinto, Tiago; Sousa, Teresa; Faria, Miguel A; Rocha, Maria Sofia; Menezes-Pinto, Daniela; Esteves-Monteiro, Marisa; Magro, Fernando; Dias-Pereira, Patrícia; Duarte-Araújo, Margarida; Morato, Manuela.

Afiliación

Ferreira-Duarte M; Laboratory of Pharmacology, Department of Drug Sciences, Faculty of Pharmacy of University of Porto (FFUP), 4050-313 Porto, Portugal.
Rodrigues-Pinto T; LAQV-REQUIMTE, Faculty of Pharmacy of University of Porto (FFUP), 4050-313 Porto, Portugal.
Sousa T; Laboratory of Pharmacology, Department of Drug Sciences, Faculty of Pharmacy of University of Porto (FFUP), 4050-313 Porto, Portugal.
Faria MA; Unit of Pharmacology and Therapeutics, Department of Biomedicine, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.
Rocha MS; Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar, University of Porto (ICBAS-UP), 4050-313 Porto, Portugal.
Menezes-Pinto D; LAQV-REQUIMTE, Faculty of Pharmacy of University of Porto (FFUP), 4050-313 Porto, Portugal.
Esteves-Monteiro M; Laboratory of Pharmacology, Department of Drug Sciences, Faculty of Pharmacy of University of Porto (FFUP), 4050-313 Porto, Portugal.
Magro F; LAQV-REQUIMTE, Faculty of Pharmacy of University of Porto (FFUP), 4050-313 Porto, Portugal.
Dias-Pereira P; Laboratory of Pharmacology, Department of Drug Sciences, Faculty of Pharmacy of University of Porto (FFUP), 4050-313 Porto, Portugal.
Duarte-Araújo M; Laboratory of Pharmacology, Department of Drug Sciences, Faculty of Pharmacy of University of Porto (FFUP), 4050-313 Porto, Portugal.
Morato M; Unit of Pharmacology and Therapeutics, Department of Biomedicine, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.

Int J Mol Sci ; 22(9)2021 May 03.

Article en En | MEDLINE | ID: mdl-34063607

Asunto(s)

Angiotensina II/genética; Colitis/genética; Enfermedades Inflamatorias del Intestino/genética; Sistema Renina-Angiotensina/genética; Antagonistas de Receptores de Angiotensina/farmacología; Animales; Colitis/fisiopatología; Colon/metabolismo; Colon/patología; Sistema Nervioso Entérico/metabolismo; Sistema Nervioso Entérico/patología; Humanos; Enfermedades Inflamatorias del Intestino/patología; Células Intersticiales de Cajal/metabolismo; Células Intersticiales de Cajal/patología; Masculino; Contracción Muscular/genética; Contracción Muscular/fisiología; Músculo Liso Vascular/efectos de los fármacos; Neuroglía/metabolismo; Neuroglía/patología; Óxido Nítrico/metabolismo; Ratas; Receptor de Angiotensina Tipo 1/genética; Receptor de Angiotensina Tipo 2/genética; Transmisión Sináptica/genética

Palabras clave

AT1 and AT2 receptors; EGC; IBD; ICC; TNBS-induced colitis; angiotensin II; colonic dysmotility; enteric glial cells; inflammatory bowel disease; interstitial cells of Cajal; nitric oxide

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sistema Renina-Angiotensina / Angiotensina II / Enfermedades Inflamatorias del Intestino / Colitis Límite: Animals / Humans / Male Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Portugal

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