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The Combination of Metabolic Posterior Cingulate Cortical Abnormalities and Structural Asymmetries Improves the Differential Diagnosis Between Primary Progressive Aphasia and Alzheimer's Disease.
Mitolo, Micaela; Stanzani-Maserati, Michelangelo; Manners, David N; Capellari, Sabina; Testa, Claudia; Talozzi, Lia; Poda, Roberto; Oppi, Federico; Evangelisti, Stefania; Gramegna, Laura L; Magarelli, Silvia; Pantieri, Roberta; Liguori, Rocco; Lodi, Raffaele; Tonon, Caterina.
Afiliación
  • Mitolo M; Functional and Molecular Neuroimaging Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, OUC Neurologia, Bologna, Italy.
  • Stanzani-Maserati M; IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Clinica Neurologica, Bologna, Italy.
  • Manners DN; Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy.
  • Capellari S; IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Clinica Neurologica, Bologna, Italy.
  • Testa C; Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy.
  • Talozzi L; Department of Physics and Astronomy, University of Bologna, Bologna, Italy.
  • Poda R; Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy.
  • Oppi F; IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Clinica Neurologica, Bologna, Italy.
  • Evangelisti S; IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Clinica Neurologica, Bologna, Italy.
  • Gramegna LL; Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy.
  • Magarelli S; Functional and Molecular Neuroimaging Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, OUC Neurologia, Bologna, Italy.
  • Pantieri R; Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy.
  • Liguori R; IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Neurologia, Bologna, Italy.
  • Lodi R; IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Neurologia, Bologna, Italy.
  • Tonon C; IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Clinica Neurologica, Bologna, Italy.
J Alzheimers Dis ; 82(4): 1467-1473, 2021.
Article en En | MEDLINE | ID: mdl-34151798
ABSTRACT
Differential diagnosis between primary progressive aphasia (PPA) and Alzheimer's disease (AD) could be difficult if based on clinical grounds alone. We evaluated the combination of proton MR spectroscopy of posterior cingulate cortex (PCC) and quantitative structural imaging asymmetries to differentiate PPA from AD patients. A greater left-lateralized temporo-parietal atrophy (higher accuracy for the PCC, 81.4%) and metabolic neurodegenerative changes in PCC (accuracy 76.8%) was demonstrated in PPA versus AD. The combined multiparametric approach increased the accuracy to 94%in the differential diagnosis between these two neurodegenerative diseases.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Atrofia / Espectroscopía de Resonancia Magnética / Afasia Progresiva Primaria / Diagnóstico Diferencial / Enfermedad de Alzheimer / Giro del Cíngulo Tipo de estudio: Diagnostic_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Italia
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Atrofia / Espectroscopía de Resonancia Magnética / Afasia Progresiva Primaria / Diagnóstico Diferencial / Enfermedad de Alzheimer / Giro del Cíngulo Tipo de estudio: Diagnostic_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Italia