Components and Mechanisms of Nuclear Mechanotransduction.
Annu Rev Cell Dev Biol
; 37: 233-256, 2021 10 06.
Article
en En
| MEDLINE
| ID: mdl-34213953
ABSTRACT
The cell nucleus is best known as the container of the genome. Its envelope provides a barrier for passive macromolecule diffusion, which enhances the control of gene expression. As its largest and stiffest organelle, the nucleus also defines the minimal space requirements of a cell. Internal or external pressures that deform a cell to its physical limits cause a corresponding nuclear deformation. Evidence is consolidating that the nucleus, in addition to its genetic functions, serves as a physical sensing device for critical cell body deformation. Nuclear mechanotransduction allows cells to adapt their acute behaviors, mechanical stability, paracrine signaling, and fate to their physical surroundings. This review summarizes the basic chemical and mechanical properties of nuclear components, and how these properties are thought to be utilized for mechanosensing.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Núcleo Celular
/
Mecanotransducción Celular
Idioma:
En
Revista:
Annu Rev Cell Dev Biol
Asunto de la revista:
BIOLOGIA
Año:
2021
Tipo del documento:
Article