Endovascular administration of magnetized nanocarriers targeting brain delivery after stroke.
J Cereb Blood Flow Metab
; 42(2): 237-252, 2022 02.
Article
en En
| MEDLINE
| ID: mdl-34229512
ABSTRACT
The increasing use of mechanical thrombectomy in stroke management has opened the window to local intraarterial brain delivery of therapeutic agents. In this context, the use of nanomedicine could further improve the delivery of new treatments for specific brain targeting, tracking and guidance. In this study we take advantage of this new endovascular approach to deliver biocompatible poly(D-L-lactic-co-glycolic acid) (PLGA) nanocapsules functionalized with superparamagnetic iron oxide nanoparticles and Cy7.5 for magnetic targeting, magnetic resonance and fluorescent molecular imaging. A complete biodistribution study in naïve (n = 59) and ischemic (n = 51) mice receiving intravenous or intraarterial nanocapsules, with two different magnet devices and imaged from 30 min to 48 h, showed an extraordinary advantage of the intraarterial route for brain delivery with a specific improvement in cortical targeting when using a magnetic device in both control and ischemic conditions. Safety was evaluated in ischemic mice (n = 69) showing no signs of systemic toxicity nor increasing mortality, infarct lesions or hemorrhages. In conclusion, the challenging brain delivery of therapeutic nanomaterials could be efficiently and safely overcome with a controlled endovascular administration and magnetic targeting, which could be considered in the context of endovascular interventions for the delivery of multiple treatments for stroke.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Carbocianinas
/
Imagen por Resonancia Magnética
/
Medios de Contraste
/
Accidente Cerebrovascular
/
Nanocápsulas
/
Campos Magnéticos
/
Imagen Óptica
/
Nanopartículas Magnéticas de Óxido de Hierro
Tipo de estudio:
Guideline
Límite:
Animals
Idioma:
En
Revista:
J Cereb Blood Flow Metab
Año:
2022
Tipo del documento:
Article
País de afiliación:
España