PML/RARA destabilization by hyperthermia: a new model for oncogenic fusion protein degradation?

Wu, Hsin Chieh; Rérolle, Domitille; de Thé, Hugues

Wu, Hsin Chieh; Rérolle, Domitille; de Thé, Hugues.

Afiliación

Wu HC; Collège de France, Oncologie Cellulaire et Moléculaire, PSL University, INSERM UMR 1050, CNRS UMR 7241, Paris, France.
Rérolle D; INSERM UMR 944, CNRS UMR 7212, Université de Paris, IRSL, Hôpital St. Louis, Paris, France.
de Thé H; Collège de France, Oncologie Cellulaire et Moléculaire, PSL University, INSERM UMR 1050, CNRS UMR 7241, Paris, France.

Blood Cancer Discov ; 2(4): 300-301, 2021 06 10.

Article en En | MEDLINE | ID: mdl-34230915

ABSTRACT

ABSTRACT

In this issue, Maimaitiyiming and colleagues demonstrate thermic stress-induced PML/RARA oncogenic fusion protein destabilization driven by corepressor aggregation. Hyperthermia synergizes with PML/RARA degradation by ATO and may circumvent ATO-resistance in historical APL patients. This novel approach could be extended to other corepressor-associated oncogenic fusion proteins.

Asunto(s)

Arsenicales; Hipertermia Inducida; Leucemia Promielocítica Aguda; Trióxido de Arsénico; Arsenicales/farmacología; Humanos; Leucemia Promielocítica Aguda/metabolismo; Óxidos/farmacología; Proteolisis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Arsenicales / Leucemia Promielocítica Aguda / Hipertermia Inducida Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Blood Cancer Discov Año: 2021 Tipo del documento: Article País de afiliación: Francia

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