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Generation of T-cell-redirecting bispecific antibodies with differentiated profiles of cytokine release and biodistribution by CD3 affinity tuning.
Haber, Lauric; Olson, Kara; Kelly, Marcus P; Crawford, Alison; DiLillo, David J; Tavaré, Richard; Ullman, Erica; Mao, Shu; Canova, Lauren; Sineshchekova, Olga; Finney, Jennifer; Pawashe, Arpita; Patel, Supriya; McKay, Ryan; Rizvi, Sahar; Damko, Ermelinda; Chiu, Danica; Vazzana, Kristin; Ram, Priyanka; Mohrs, Katja; D'Orvilliers, Amanda; Xiao, Jenny; Makonnen, Sosina; Hickey, Carlos; Arnold, Cody; Giurleo, Jason; Chen, Ya Ping; Thwaites, Courtney; Dudgeon, Drew; Bray, Kevin; Rafique, Ashique; Huang, Tammy; Delfino, Frank; Hermann, Aynur; Kirshner, Jessica R; Retter, Marc W; Babb, Robert; MacDonald, Douglas; Chen, Gang; Olson, William C; Thurston, Gavin; Davis, Samuel; Lin, John C; Smith, Eric.
Afiliación
  • Haber L; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA. Lauric.haber@regeneron.com.
  • Olson K; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Kelly MP; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Crawford A; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • DiLillo DJ; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Tavaré R; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Ullman E; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Mao S; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Canova L; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Sineshchekova O; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Finney J; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Pawashe A; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Patel S; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • McKay R; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Rizvi S; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Damko E; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Chiu D; AstraZeneca, Cambridge, UK.
  • Vazzana K; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Ram P; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Mohrs K; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • D'Orvilliers A; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Xiao J; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Makonnen S; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Hickey C; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Arnold C; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Giurleo J; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Chen YP; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Thwaites C; Lonza, Slough, UK.
  • Dudgeon D; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Bray K; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Rafique A; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Huang T; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Delfino F; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Hermann A; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Kirshner JR; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Retter MW; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Babb R; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • MacDonald D; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Chen G; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Olson WC; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Thurston G; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Davis S; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Lin JC; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
  • Smith E; Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 10591, USA.
Sci Rep ; 11(1): 14397, 2021 07 13.
Article en En | MEDLINE | ID: mdl-34257348
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Citocinas / Complejo CD3 / Anticuerpos Biespecíficos Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Citocinas / Complejo CD3 / Anticuerpos Biespecíficos Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos