Yi-Qi-Jian-Pi formula modulates the PI3K/AKT signaling pathway to attenuate acute-on-chronic liver failure by suppressing hypoxic injury and apoptosis in vivo and in vitro.

Tang, Li; Wang, Feixia; Xiao, Lingyan; Shen, Min; Xia, Siwei; Zhang, Zili; Zhang, Feng; Zheng, Shizhong; Tan, Shanzhong

Tang, Li; Wang, Feixia; Xiao, Lingyan; Shen, Min; Xia, Siwei; Zhang, Zili; Zhang, Feng; Zheng, Shizhong; Tan, Shanzhong.

Afiliación

Tang L; Department of Integrated TCM and Western Medicine, Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210003, China; Department of Gastroenterology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210001, China. Electro
Wang F; Department of Integrated TCM and Western Medicine, Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210003, China; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Material Medical, School of Pharmacy, Nanjing University of Chinese Medicine, Nan
Xiao L; Department of Integrated TCM and Western Medicine, Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210003, China.
Shen M; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Material Medical, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Xia S; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Material Medical, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Zhang Z; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Material Medical, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Zhang F; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Material Medical, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Zheng S; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Material Medical, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Tan S; Department of Integrated TCM and Western Medicine, Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210003, China. Electronic address: doctor_tsz@aliyun.com.

J Ethnopharmacol ; 280: 114411, 2021 Nov 15.

Article en En | MEDLINE | ID: mdl-34265380

Asunto(s)

Enfermedad Hepática Inducida por Sustancias y Drogas/tratamiento farmacológico; Medicamentos Herbarios Chinos/uso terapéutico; Enfermedad Hepática en Estado Terminal/tratamiento farmacológico; Fosfatidilinositol 3-Quinasas/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Animales; Enfermedad Hepática Inducida por Sustancias y Drogas/metabolismo; Relación Dosis-Respuesta a Droga; Medicamentos Herbarios Chinos/administración & dosificación; Enfermedad Hepática en Estado Terminal/inducido químicamente; Regulación de la Expresión Génica/efectos de los fármacos; Hepatocitos/efectos de los fármacos; Hepatocitos/metabolismo; Hígado/efectos de los fármacos; Hígado/metabolismo; Masculino; Metilprednisolona/uso terapéutico; Fosfatidilinositol 3-Quinasas/genética; Proteínas Proto-Oncogénicas c-akt/genética; Distribución Aleatoria; Ratas; Ratas Sprague-Dawley

Palabras clave

Apoptosis; Hypoxic liver injury; Liver failure; Network pharmacology; Yi-Qi-Jian-Pi formula

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Medicamentos Herbarios Chinos / Fosfatidilinositol 3-Quinasas / Proteínas Proto-Oncogénicas c-akt / Enfermedad Hepática Inducida por Sustancias y Drogas / Enfermedad Hepática en Estado Terminal Límite: Animals Idioma: En Revista: J Ethnopharmacol Año: 2021 Tipo del documento: Article

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