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The Inflammatory Cytokine Profile Associated With Liver Damage Is Broader and Stronger in Patients With Chronic Hepatitis B Compared to Patients With Acute Hepatitis B.
Johnson Valiente, Alexandra; Liem, Kin Seng; Schwarz, Kathleen B; Rosenthal, Philip; Murray, Karen F; Mogul, Douglas; Teckman, Jeffery; Rodriguez-Baez, Norberto; Schwarzenberg, Sarah Jane; Feld, Jordan J; Wong, David K; Lewis-Ximenez, Lia L; Lauer, Georg; Hansen, Bettina E; Ling, Simon C; Janssen, Harry L A; Gehring, Adam J.
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  • Johnson Valiente A; Department of Immunology, University of Toronto, Ontario, Canada.
  • Liem KS; Toronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
  • Schwarz KB; Toronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
  • Rosenthal P; Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Murray KF; Division of Pediatric Gastroenterology, University of California, San Diego, San Diego, California, USA.
  • Mogul D; Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland, USA.
  • Teckman J; Department of Pediatrics, University of California, San Francisco , San Francisco, California, USA.
  • Rodriguez-Baez N; Seattle Children's Hospital, Seattle, Washington, USA.
  • Schwarzenberg SJ; Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland, USA.
  • Feld JJ; Department of Pediatrics, Saint Louis University, St Louis, Missouri, USA.
  • Wong DK; Department of Pediatrics, University of Texas Southwestern, Dallas, Texas, USA.
  • Lewis-Ximenez LL; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
  • Lauer G; Toronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
  • Hansen BE; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
  • Ling SC; Toronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
  • Janssen HLA; Viral Hepatitis Laboratory, Oswaldo Cruz Institute, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
  • Gehring AJ; Massachusetts General Hospital, Boston, Massachusetts, USA.
J Infect Dis ; 225(3): 470-475, 2022 02 01.
Article en En | MEDLINE | ID: mdl-34286845
ABSTRACT
Liver damage in hepatitis B is immune driven and correlates with inflammatory markers in patient serum. There is no comparison of these markers to determine if inflammatory profiles are distinct to different types of liver damage across patients at different stages of disease. We measured 25 inflammatory markers in patients with acute hepatitis B and chronic hepatitis B with hepatitis B e antigen seroconversion and chronic patients stopping nucleoside analogue therapy. Myeloid markers dominated the inflammatory profile in all stages of hepatitis B. More inflammatory markers were detectable in chronic patients, including elevated concentrations of cytotoxic effectors Fas ligand, TRAIL, and TNF-α.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Hepatitis B Crónica / Hepatitis B Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: J Infect Dis Año: 2022 Tipo del documento: Article País de afiliación: Canadá
Texto completo
Imprimir
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PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Hepatitis B Crónica / Hepatitis B Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: J Infect Dis Año: 2022 Tipo del documento: Article País de afiliación: Canadá