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A Deep Learning-Based Approach for Glomeruli Instance Segmentation from Multistained Renal Biopsy Pathologic Images.
Jiang, Lei; Chen, Wenkai; Dong, Bao; Mei, Ke; Zhu, Chuang; Liu, Jun; Cai, Meishun; Yan, Yu; Wang, Gongwei; Zuo, Li; Shi, Hongxia.
Afiliación
  • Jiang L; Electron Microscope Lab, Peking University People's Hospital, Beijing, China.
  • Chen W; School of Information and Communication Engineering, Beijing University of Posts and Telecommunications, Beijing, China.
  • Dong B; Department of Nephrology, Peking University People's Hospital, Beijing, China.
  • Mei K; School of Information and Communication Engineering, Beijing University of Posts and Telecommunications, Beijing, China.
  • Zhu C; School of Information and Communication Engineering, Beijing University of Posts and Telecommunications, Beijing, China. Electronic address: czhu@bupt.edu.cn.
  • Liu J; School of Information and Communication Engineering, Beijing University of Posts and Telecommunications, Beijing, China.
  • Cai M; Department of Nephrology, Peking University People's Hospital, Beijing, China.
  • Yan Y; Department of Nephrology, Peking University People's Hospital, Beijing, China.
  • Wang G; Department of Pathology, Peking University People's Hospital, Beijing, China.
  • Zuo L; Department of Nephrology, Peking University People's Hospital, Beijing, China.
  • Shi H; Electron Microscope Lab, Peking University People's Hospital, Beijing, China. Electronic address: hxshi55@sina.com.
Am J Pathol ; 191(8): 1431-1441, 2021 08.
Article en En | MEDLINE | ID: mdl-34294192
ABSTRACT
Glomeruli instance segmentation from pathologic images is a fundamental step in the automatic analysis of renal biopsies. Glomerular histologic manifestations vary widely among diseases and cases, and several special staining methods are necessary for pathologic diagnosis. A robust model is needed to segment and classify glomeruli with different staining methods and apply in cases with various glomerular pathologic changes. Herein, pathologic images from renal biopsy slides stained with three basic special staining methods were used to build the data sets. The snapshot group included 1970 glomeruli from 516 patients, and the whole-slide image group included 8665 glomeruli from 148 patients. Cascade Mask region-based convolutional neural net architecture was trained to detect, classify, and segment glomeruli into three categories i) GN, structural normal; ii) global sclerosis; and iii) glomerular with other lesions. In the snapshot group, total glomeruli, GN, global sclerosis, and glomerular with other lesions achieved an F1 score of 0.914, 0.896, 0.681, and 0.756, respectively, which were comparable with those in the whole-slide image group (0.940, 0.839, 0.806, and 0.753, respectively). Among the three categories, GN achieved the best instance segmentation effect in both groups, as determined by average precision, average recall, F1 score, and Mask mean Intersection over Union. The present model segments and classifies multistained glomeruli with efficiency and robustness. It can be applied as the first step for more detailed glomerular histologic analysis.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Interpretación de Imagen Asistida por Computador / Aprendizaje Profundo / Enfermedades Renales / Glomérulos Renales Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Am J Pathol Año: 2021 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Interpretación de Imagen Asistida por Computador / Aprendizaje Profundo / Enfermedades Renales / Glomérulos Renales Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Am J Pathol Año: 2021 Tipo del documento: Article País de afiliación: China