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Higher circulating EGF levels associate with a decreased risk of IgE sensitization in young children.
Reinert-Hartwall, Linnea; Siljander, Heli; Härkönen, Taina; Vatanen, Tommi; Ilonen, Jorma; Niemelä, Onni; Luopajärvi, Kristiina; Dorshakova, Natalya; Mokurov, Sergei; Peet, Aleksandr; Tillmann, Vallo; Uibo, Raivo; Knip, Mikael; Vaarala, Outi; Honkanen, Jarno.
Afiliación
  • Reinert-Hartwall L; Research Program for Translational Immunology, University of Helsinki, Helsinki, Finland.
  • Siljander H; Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland.
  • Härkönen T; Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Vatanen T; Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland.
  • Ilonen J; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Niemelä O; Liggins Institute, University of Auckland, Auckland, New Zealand.
  • Luopajärvi K; Immunogenetics Laboratory, University of Turku, Turku, Finland.
  • Dorshakova N; Department of Laboratory Medicine and Medical Research Unit, Seinäjoki Central Hospital and University of Tampere, Seinäjoki, Finland.
  • Mokurov S; Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland.
  • Peet A; Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Tillmann V; Department of Family Medicine, Petrozavodsk State University, Petrozavodsk, Russia.
  • Uibo R; Ministry of Health and Social Development, Karelian Republic of the Russian Federation, Petrozavodsk, Russia.
  • Knip M; Children's Clinic of Tartu University Hospital, Tartu, Estonia.
  • Vaarala O; Children's Clinic of Tartu University Hospital, Tartu, Estonia.
  • Honkanen J; Department of Immunology, Institute of Biomedicine and Translational Medicine, Centre of Excellence for Translational Medicine, University of Tartu, Tartu, Estonia.
Pediatr Allergy Immunol ; 33(1): e13613, 2022 01.
Article en En | MEDLINE | ID: mdl-34379817
BACKGROUND: Decreased exposure to microbial agents in industrialized countries and urban living areas is considered as a risk factor of developing immune-mediated diseases, such as allergies and asthma. Epithelial surfaces in the gastrointestinal and respiratory tracts and in the skin constitute the primary areas in contact with the environmental microbial load. METHODS: We analyzed the levels of 30 cytokines and growth factors in serum or plasma as markers of the immune maturation in the participants in the DIABIMMUNE study from Russian Karelia (n = 60), Estonia (n = 83) and Finland (n = 89), three neighboring countries with remarkable differences in the incidences of allergies, asthma and autoimmune diseases. RESULTS: We observed an upregulation of T helper cell signature cytokines during the first 12 months of life, reflecting natural development of adaptive immune responses. During the first years of life, circulating concentrations of epidermal growth factor (EGF) were significantly higher, especially in Russian children compared with Finnish children. The children who developed IgE sensitization showed lower levels of EGF than those without such responses. CONCLUSION: Our results suggest that low circulating EGF levels associate with the risk of allergies possibly via the effects on the epithelial integrity and mucosal homeostasis.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Asma / Hipersensibilidad Tipo de estudio: Etiology_studies Límite: Child / Child, preschool / Humans Idioma: En Revista: Pediatr Allergy Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA / PEDIATRIA Año: 2022 Tipo del documento: Article País de afiliación: Finlandia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Asma / Hipersensibilidad Tipo de estudio: Etiology_studies Límite: Child / Child, preschool / Humans Idioma: En Revista: Pediatr Allergy Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA / PEDIATRIA Año: 2022 Tipo del documento: Article País de afiliación: Finlandia