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Analysis of complex protein elution behavior in preparative ion exchange processes using a colloidal particle adsorption model.
Briskot, Till; Hahn, Tobias; Huuk, Thiemo; Wang, Gang; Kluters, Simon; Studts, Joey; Wittkopp, Felix; Winderl, Johannes; Schwan, Peter; Hagemann, Isabell; Kaiser, Klaus; Trapp, Anja; Stamm, Serge M; Koehn, Jadranka; Malmquist, Gunnar; Hubbuch, Jürgen.
Afiliación
  • Briskot T; GoSilico GmbH, Kriegsstr. 240, Karlsruhe 76135, Germany; Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 2, Karlsruhe 76131, Germany.
  • Hahn T; GoSilico GmbH, Kriegsstr. 240, Karlsruhe 76135, Germany.
  • Huuk T; GoSilico GmbH, Kriegsstr. 240, Karlsruhe 76135, Germany.
  • Wang G; Late Stage DSP Development, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß 88397, Germany.
  • Kluters S; Late Stage DSP Development, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß 88397, Germany.
  • Studts J; Late Stage DSP Development, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß 88397, Germany.
  • Wittkopp F; Pharma Research and Early Development (pRED), Roche Innovation Center Munich, Roche Diagnostics GmbH, Nonnenwald 2, Penzberg 82377, Germany.
  • Winderl J; Roche Pharma Technical Development, Roche Diagnostics GmbH, Nonnenwald 2, Penzberg 82377, Germany.
  • Schwan P; Bayer AG, Leverkusen 51368, Germany.
  • Hagemann I; Bayer AG, Leverkusen 51368, Germany.
  • Kaiser K; Bayer AG, Leverkusen 51368, Germany.
  • Trapp A; Process Science & Innovation, Rentschler Biopharma SE, Erwin Rentschler Str. 21, Laupheim 88471, Germany.
  • Stamm SM; Process Science & Innovation, Rentschler Biopharma SE, Erwin Rentschler Str. 21, Laupheim 88471, Germany.
  • Koehn J; Process Science & Innovation, Rentschler Biopharma SE, Erwin Rentschler Str. 21, Laupheim 88471, Germany.
  • Malmquist G; R&D, Cytiva, Björkgatan 30, Uppsala 753 23, Sweden.
  • Hubbuch J; Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 2, Karlsruhe 76131, Germany. Electronic address: juergen.hubbuch@kit.edu.
J Chromatogr A ; 1654: 462439, 2021 Sep 27.
Article en En | MEDLINE | ID: mdl-34384923
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas / Cromatografía por Intercambio Iónico / Modelos Químicos / Anticuerpos Monoclonales Idioma: En Revista: J Chromatogr A Año: 2021 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas / Cromatografía por Intercambio Iónico / Modelos Químicos / Anticuerpos Monoclonales Idioma: En Revista: J Chromatogr A Año: 2021 Tipo del documento: Article País de afiliación: Alemania