Stem cell therapy for Crohn's disease: systematic review and meta-analysis of preclinical and clinical studies.
Stem Cell Res Ther
; 12(1): 463, 2021 08 18.
Article
en En
| MEDLINE
| ID: mdl-34407875
ABSTRACT
BACKGROUND:
We explored whether stem cell therapy was effective for animal models and patients with Crohn's disease (CD).METHODS:
We searched five online databases. The relative outcomes were analyzed with the aid of GetData Graph Digitizer 2.26 and Stata 16.0 software. The SYRCLE risk of bias tool and the MINORS tool were used to assess study quality.RESULTS:
We evaluated 46 studies including 28 animal works (n = 567) and 18 human trials (n = 360). In the animal studies, the disease activity index dramatically decreased in the mesenchymal stem cell (MSC) treatment groups compared to the control group. Rats and mice receiving MSCs exhibited longer colons [mice standardized mean difference (SMD) 2.84, P = 0.000; rats SMD 1.44, P = 0.029], lower histopathological scores (mice SMD - 4.58, p = 0.000; rats SMD - 1.41, P = 0.000) and lower myeloperoxidase levels (SMD - 6.22, P = 0.000). In clinical trials, stem cell transplantation reduced the CD activity index (SMD - 2.10, P = 0.000), the CD endoscopic index of severity (SMD - 3.40, P = 0.000) and simplified endoscopy score for CD (SMD - 1.71, P = 0.000) and improved the inflammatory bowel disease questionnaire score (SMD 1.33, P = 0.305) compared to control values. CD patients maintained high remission rates for 3-24 months after transplantation.CONCLUSIONS:
Stem cell transplantation is a valuable supplementary therapy for CD.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad de Crohn
/
Trasplante de Células Madre Hematopoyéticas
/
Células Madre Mesenquimatosas
Tipo de estudio:
Prognostic_studies
/
Systematic_reviews
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Stem Cell Res Ther
Año:
2021
Tipo del documento:
Article
País de afiliación:
China