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Analysis of m6A methylation in skin tissues of different sex Liaoning cashmere goats.
Wang, Yanru; Li, Gaoqian; Zhang, Xinjiang; Zheng, Yuanyuan; Guo, Suling; Guo, Dan; Zhang, Xinghui; Dou, Xingtang; Hui, Taiyu; Yue, Chang; Sun, Jiaming; Guo, Suping; Bai, Zhixian; Cai, Weidong; Fan, Yixing; Wang, Zeying; Bai, Wenlin.
Afiliación
  • Wang Y; College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, China.
  • Li G; College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
  • Zhang X; College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, China.
  • Zheng Y; College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, China.
  • Guo S; Prosperous Community, Changshun Town, China.
  • Guo D; Department of Science and Technology of Liaoning Province, Shenyang, China.
  • Zhang X; Liaoning Modern Agricultural Production Base Construction Engineering Center, Academy of Animal Husbandry Science of Liaoning Province, Liaoyang, China.
  • Dou X; Liaoning Modern Agricultural Production Base Construction Engineering Center, Academy of Animal Husbandry Science of Liaoning Province, Liaoyang, China.
  • Hui T; College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, China.
  • Yue C; College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, China.
  • Sun J; College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, China.
  • Guo S; College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, China.
  • Bai Z; College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, China.
  • Cai W; College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, China.
  • Fan Y; College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, China.
  • Wang Z; College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, China.
  • Bai W; College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, China.
Anim Biotechnol ; 34(2): 310-320, 2023 Apr.
Article en En | MEDLINE | ID: mdl-34431751
N6-methyladenosine (m6A) is the most frequent internal modification of mRNA and lncRNA in eukaryotes. We used two high-throughput sequencing method, m6A-seq and RNA-seq to identify pivotal m6A-modified genes in cashmere fineness and fiber growth. 8062 m6A peaks were detected by m6A-seq, including 2157 upregulated and 6445 downregulated. Furthermore, by comparing m6A-modified genes of the male Liaoning Cashmere Goat (M-LCG) and female Liaoning Cashmere Goat (F-LCG) skin tissues, we get 862 differentially expressed m6A-modified genes. To identify differently expressed m6A genes associated with cashmere fineness, 11 genes were selected for validation using real time fluorescent quantitative PCR in M-LCG and F-LCG. This study provides an acadamic basis on the molecular regulation mechanism of m6A modification in cashmere growth process.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piel / Cabras Límite: Animals Idioma: En Revista: Anim Biotechnol Asunto de la revista: BIOTECNOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piel / Cabras Límite: Animals Idioma: En Revista: Anim Biotechnol Asunto de la revista: BIOTECNOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China