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Epigenomic and transcriptional profiling identifies impaired glyoxylate detoxification in NAFLD as a risk factor for hyperoxaluria.
Gianmoena, Kathrin; Gasparoni, Nina; Jashari, Adelina; Gabrys, Philipp; Grgas, Katharina; Ghallab, Ahmed; Nordström, Karl; Gasparoni, Gilles; Reinders, Jörg; Edlund, Karolina; Godoy, Patricio; Schriewer, Alexander; Hayen, Heiko; Hudert, Christian A; Damm, Georg; Seehofer, Daniel; Weiss, Thomas S; Boor, Peter; Anders, Hans-Joachim; Motrapu, Manga; Jansen, Peter; Schiergens, Tobias S; Falk-Paulsen, Maren; Rosenstiel, Philip; Lisowski, Clivia; Salido, Eduardo; Marchan, Rosemarie; Walter, Jörn; Hengstler, Jan G; Cadenas, Cristina.
Afiliación
  • Gianmoena K; Department of Toxicology, Leibniz-Research Centre for Working Environment and Human Factors at the TU Dortmund (IfADo), 44139 Dortmund, Germany.
  • Gasparoni N; Department of Genetics, Saarland University, 66123 Saarbrücken, Germany.
  • Jashari A; Department of Toxicology, Leibniz-Research Centre for Working Environment and Human Factors at the TU Dortmund (IfADo), 44139 Dortmund, Germany.
  • Gabrys P; Department of Toxicology, Leibniz-Research Centre for Working Environment and Human Factors at the TU Dortmund (IfADo), 44139 Dortmund, Germany.
  • Grgas K; Department of Toxicology, Leibniz-Research Centre for Working Environment and Human Factors at the TU Dortmund (IfADo), 44139 Dortmund, Germany.
  • Ghallab A; Department of Toxicology, Leibniz-Research Centre for Working Environment and Human Factors at the TU Dortmund (IfADo), 44139 Dortmund, Germany; Department of Forensic and Veterinary Toxicology, Faculty of Veterinary Medicine, South Valley University, 83523 Qena, Egypt.
  • Nordström K; Department of Genetics, Saarland University, 66123 Saarbrücken, Germany.
  • Gasparoni G; Department of Genetics, Saarland University, 66123 Saarbrücken, Germany.
  • Reinders J; Department of Toxicology, Leibniz-Research Centre for Working Environment and Human Factors at the TU Dortmund (IfADo), 44139 Dortmund, Germany.
  • Edlund K; Department of Toxicology, Leibniz-Research Centre for Working Environment and Human Factors at the TU Dortmund (IfADo), 44139 Dortmund, Germany.
  • Godoy P; Department of Toxicology, Leibniz-Research Centre for Working Environment and Human Factors at the TU Dortmund (IfADo), 44139 Dortmund, Germany.
  • Schriewer A; Department of Analytical Chemistry, Institute of Inorganic and Analytical Chemistry, University of Münster, 48149 Münster, Germany.
  • Hayen H; Department of Analytical Chemistry, Institute of Inorganic and Analytical Chemistry, University of Münster, 48149 Münster, Germany.
  • Hudert CA; Department of Pediatric Gastroenterology, Hepatology and Metabolic Diseases, Charité-University Medicine Berlin, 13353 Berlin, Germany.
  • Damm G; Department of Hepatobiliary Surgery and Visceral Transplantation, University of Leipzig, 04103 Leipzig, Germany; Department of General-, Visceral- and Transplantation Surgery, Charité University Medicine Berlin, 13353 Berlin, Germany.
  • Seehofer D; Department of Hepatobiliary Surgery and Visceral Transplantation, University of Leipzig, 04103 Leipzig, Germany; Department of General-, Visceral- and Transplantation Surgery, Charité University Medicine Berlin, 13353 Berlin, Germany.
  • Weiss TS; University Children Hospital (KUNO), University Hospital Regensburg, 93053 Regensburg, Germany.
  • Boor P; Institute of Pathology and Department of Nephrology, University Clinic of RWTH Aachen, 52074 Aachen, Germany.
  • Anders HJ; Department of Medicine IV, Renal Division, University Hospital, Ludwig-Maximilians-University Munich, 80336 Munich, Germany.
  • Motrapu M; Department of Medicine IV, Renal Division, University Hospital, Ludwig-Maximilians-University Munich, 80336 Munich, Germany.
  • Jansen P; Maastricht Centre for Systems Biology, University of Maastricht, 6229 Maastricht, the Netherlands.
  • Schiergens TS; Biobank of the Department of General, Visceral and Transplant Surgery, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.
  • Falk-Paulsen M; Institute of Clinical Molecular Biology (IKMB), Kiel University and University Hospital Schleswig Holstein, Campus Kiel, 24105 Kiel, Germany.
  • Rosenstiel P; Institute of Clinical Molecular Biology (IKMB), Kiel University and University Hospital Schleswig Holstein, Campus Kiel, 24105 Kiel, Germany.
  • Lisowski C; Institute of Experimental Immunology, University Hospital Bonn, Rheinische-Friedrich-Wilhelms University Bonn, 53127 Bonn, Germany.
  • Salido E; Hospital Universitario de Canarias, Universidad La Laguna, CIBERER, 38320 Tenerife, Spain.
  • Marchan R; Department of Toxicology, Leibniz-Research Centre for Working Environment and Human Factors at the TU Dortmund (IfADo), 44139 Dortmund, Germany.
  • Walter J; Department of Genetics, Saarland University, 66123 Saarbrücken, Germany.
  • Hengstler JG; Department of Toxicology, Leibniz-Research Centre for Working Environment and Human Factors at the TU Dortmund (IfADo), 44139 Dortmund, Germany.
  • Cadenas C; Department of Toxicology, Leibniz-Research Centre for Working Environment and Human Factors at the TU Dortmund (IfADo), 44139 Dortmund, Germany. Electronic address: cadenas@ifado.de.
Cell Rep ; 36(8): 109526, 2021 08 24.
Article en En | MEDLINE | ID: mdl-34433051

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Hiperoxaluria / Hepatocitos / Transcriptoma / Enfermedad del Hígado Graso no Alcohólico / Epigenoma / Glioxilatos Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Animals / Humans / Male Idioma: En Revista: Cell Rep Año: 2021 Tipo del documento: Article País de afiliación: Alemania

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Hiperoxaluria / Hepatocitos / Transcriptoma / Enfermedad del Hígado Graso no Alcohólico / Epigenoma / Glioxilatos Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Animals / Humans / Male Idioma: En Revista: Cell Rep Año: 2021 Tipo del documento: Article País de afiliación: Alemania