ADAMTS, a disintegrin and metalloproteinase with thrombospondin motifs; AS, aortic valve stenosis; BMP, bone morphogenetic protein; Biomarker; CKD, chronic kidney disease; CP, C-propeptide; CUB, complement, Uegf, BMP-1; CVD, cardiovascular disease; Collagen; DMD, Duchenne muscular dystrophy; ECM, extracellular matrix; EGF, epidermal growth factor; ELISA, enzyme-linked immunosorbent assay; Fibrillogenesis; Fibrosis; HDL, high-density lipoprotein; HSC, hepatic stellate cell; HTS, hypertrophic scar; IPF, idiopathic pulmonary fibrosis; LDL, low-density lipoprotein; MI, myocardial infarction; MMP, matrix metalloproteinase; NASH, nonalcoholic steatohepatitis; NTR, netrin; OPMD, oculopharyngeal muscular dystrophy; PABPN1, poly(A)-binding protein nuclear 1; PCP, procollagen C-proteinase; PCPE, procollagen C-proteinase enhancer; PNP, procollagen N-proteinase; Proteolysis; SPC, subtilisin proprotein convertase; TGF-ß, transforming growth-factor ß; TIMP, tissue inhibitor of metalloproteinases; TSPN, thrombospondin-like N-terminal; Therapeutic target; eGFR, estimated glomerular filtration rate; mTLD, mammalian tolloid; mTLL, mammalian tolloid-like