The heterogeneity of intraductal carcinoma of the prostate is associated with different efficacy of standard first-line therapy for patients with metastatic castration-resistant prostate cancer.
Prostate
; 81(15): 1191-1201, 2021 11.
Article
en En
| MEDLINE
| ID: mdl-34435696
ABSTRACT
BACKGROUND:
To explore whether metastatic castration-resistant prostate cancer (mCRPC) patients with distinct intraductal carcinoma of the prostate (IDC-P) subtypes respond differently to abiraterone and docetaxel treatment.METHODS:
We retrospectively analyzed data of 170 mCRPC patients receiving abiraterone or docetaxel as first-line therapy. PSA response, PSA progression-free survival (PSA-PFS), radiographic progression-free survival (rPFS), and overall survival (OS) were analyzed based on the presence of IDC-P and its subpatterns.RESULTS:
IDC-P was confirmed in 91/170 (53.5%) patients. Among them 36/91 (39.6%) and 55/91 (60.4%) harbored IDC-P patterns 1 and 2, respectively. Patients with IDC-P pattern 1 shared similar clinical outcomes to those without IDC-P in both abiraterone and docetaxel treatment. However, against cases without IDC-P or with IDC-P pattern 1, patients with IDC-P pattern 2 had markedly poorer prognosis in either abiraterone (mPSA-PFS 11.9 vs. 11.1 vs. 6.1 months, p < 0.001; mrPFS 18.9 vs. 19.4 vs. 9.6 months, p < 0.001) or docetaxel (mPSA-PFS 6.2 vs. 6.6 vs. 3.0 months, p < 0.001; mrPFS 15.1 vs. 12.6 vs. 5.5 months, p < 0.001) treatment. For patients without IDC-P, docetaxel had comparable therapeutic efficacy with abiraterone. However, the efficacy of docetaxel was significantly inferior to abiraterone in patients with either IDC-P pattern 1 (mPSA-PFS 6.6 vs. 11.1 months, p = 0.021; mrPFS 12.6 vs. 19.4 months, p = 0.027) or pattern 2 (mPSA-PFS 3.0 vs. 6.1 months, p = 0.003; mrPFS 5.5 vs. 9.6 months, p = 0.007).CONCLUSION:
Compared to docetaxel, abiraterone exhibited better efficacy in patients with IDC-P of either pattern. However, IDC-P pattern 2 responded unsatisfactorily to either abiraterone or docetaxel therapy. Novel therapeutic strategies for IDC-P pattern 2 need further investigations.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
/
Neoplasias de la Próstata Resistentes a la Castración
/
Docetaxel
/
Androstenos
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Antineoplásicos
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Aged
/
Humans
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Male
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Middle aged
Idioma:
En
Revista:
Prostate
Año:
2021
Tipo del documento:
Article
País de afiliación:
China