Deciphering nutritional interventions for podocyte structure and function.
Pharmacol Res
; 172: 105852, 2021 10.
Article
en En
| MEDLINE
| ID: mdl-34450318
ABSTRACT
Despite increasing awareness and therapeutic options chronic kidney disease (CKD) is still and important health problem and glomerular diseases constitute and important percentage of CKD. Proteinuria/albuminuria is not just a marker; but it also plays a direct pathogenic role in renal disease progression of CKD. Glomerular filtration barrier (GFB) which consists of fenestrated endothelial cells, fused basal membrane and interdigitating podocyte foot process and filtration slits between foot process is the major barrier for proteinuria/albuminuria. Many glomerular diseases are characterized by disruption of GFB podocytes, foot process and slit diaphragm. Many proteinuric diseases are non-specifically targeted by therapeutic agents such as steroids and calcineurin inhibitors with systemic side effects. Thus, there is unmet need for more efficient and less toxic therapeutic options to treat glomerular diseases. In recent years, modification of dietary intake, has been gained to treat pathologic processes introducing the concept of 'food as a medicine'. The effect of various nutritional products on podocyte function and structure is also trending, especially in recent years. In the current review, we summarized the effect of nutritional interventions on podocyte function and structure.
Palabras clave
Chlorogenic acid (PubChem CID: 1794427); Curcumin (PubChem CID: 969516); Ferulic acid (PubChem CID: 445858); Food; Foot process; Genistein (PubChem CID:5280961); Nutrition; Podocyte proteinuria; Resveratrol (PubChem CID: 454154); Retinoic acid (PubChem CID: 444795); Slit diaphragm; Taurine (PubChem CID: 1123)
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Podocitos
/
Enfermedades Renales
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Pharmacol Res
Asunto de la revista:
FARMACOLOGIA
Año:
2021
Tipo del documento:
Article