Evaluation of autophagy mediators in myeloid-derived suppressor cells during human tuberculosis.
Cell Immunol
; 369: 104426, 2021 11.
Article
en En
| MEDLINE
| ID: mdl-34469846
ABSTRACT
Myeloid-derived suppressor cells (MDSC) are induced during active TB disease to restore immune homeostasis but instead exacerbate disease outcome due to chronic inflammation. Autophagy, in conventional phagocytes, ensures successful clearance of M.tb. However, autophagy has been demonstrated to induce prolonged MDSC survival. Here we investigate the relationship between autophagy mediators and MDSC in the context of active TB disease and during anti-TB therapy. We demonstrate a significant increase in MDSC frequencies in untreated active TB cases with these MDSC expressing TLR4 and significantly more mTOR and IL-6 than healthy controls, with mTOR levels decreasing during anti-TB therapy. Finally, we show that HMGB1 serum concentrations decrease in parallel with mTOR. These findings suggest a complex interplay between MDSC and autophagic mediators, potentially dependent on cellular localisation and M.tb infection state.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Autofagia
/
Tuberculosis
/
Células Supresoras de Origen Mieloide
Límite:
Humans
Idioma:
En
Revista:
Cell Immunol
Año:
2021
Tipo del documento:
Article
País de afiliación:
Sudáfrica