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Anti-angiogenic activity of azathioprine.
de Melo Bisneto, Abel Vieira; Fernandes, Amanda Silva; Velozo Sá, Vivianne de Souza; Véras, Jefferson Hollanda; Soares, Estéfane Thaíne Sodré; da Silva Santos, Aline Ferreira; Cardoso, Clever Gomes; Silveira-Lacerda, Elisângela de Paula; Carneiro, Cristiene Costa; Chen-Chen, Lee.
Afiliación
  • de Melo Bisneto AV; Laboratory of Radiobiology and Mutagenesis, Department of Genetics of Institute of Biological Sciences, Federal University of Goiás, 74690-900 Goiânia, Brazil.
  • Fernandes AS; Laboratory of Radiobiology and Mutagenesis, Department of Genetics of Institute of Biological Sciences, Federal University of Goiás, 74690-900 Goiânia, Brazil.
  • Velozo Sá VS; Laboratory of Molecular Genetics and Cytogenetics, Department of Genetics of Institute of Biological Sciences, Federal University of Goiás, 74690-900 Goiânia, Brazil.
  • Véras JH; Laboratory of Radiobiology and Mutagenesis, Department of Genetics of Institute of Biological Sciences, Federal University of Goiás, 74690-900 Goiânia, Brazil.
  • Soares ETS; Laboratory of Radiobiology and Mutagenesis, Department of Genetics of Institute of Biological Sciences, Federal University of Goiás, 74690-900 Goiânia, Brazil.
  • da Silva Santos AF; Institute of Health Sciences, Universidade Paulista - Campus Flamboyant, 74845-090 Goiânia, Brazil.
  • Cardoso CG; Department of Morphology of Institute of Biological Sciences, Federal University of Goiás, 74690-900 Goiânia, Brazil.
  • Silveira-Lacerda EP; Laboratory of Molecular Genetics and Cytogenetics, Department of Genetics of Institute of Biological Sciences, Federal University of Goiás, 74690-900 Goiânia, Brazil.
  • Carneiro CC; Institute of Health Sciences, Universidade Paulista - Campus Flamboyant, 74845-090 Goiânia, Brazil.
  • Chen-Chen L; Laboratory of Radiobiology and Mutagenesis, Department of Genetics of Institute of Biological Sciences, Federal University of Goiás, 74690-900 Goiânia, Brazil. Electronic address: chenleego@yahoo.com.br.
Microvasc Res ; 138: 104234, 2021 11.
Article en En | MEDLINE | ID: mdl-34478745
ABSTRACT
Azathioprine (AZA) is the main drug used in immunomodulatory therapy in post-transplant patients or with autoimmune diseases. However, no study has evaluated the AZA angiogenic response. Therefore, this study investigated the effects of AZA on the angiogenic process through macroscopic, histological, and immunohistochemical analyses in chick embryo chorioallantoic membrane (CAM). Our results showed potent anti-angiogenic activity of AZA at the higher concentrations tested in the CAM assay. The histological analysis of CAM confirmed this effect, since AZA induced a significant reduction in all parameters evaluated. In addition, immunohistochemical evaluation of CAM revealed that AZA decreased TGF-ß and VEGF levels, important cytokines involved in the angiogenic process. Therefore, the AZA anti-angiogenic effect identified in our study provides new information for the possible application of this drug in anticancer treatment.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Azatioprina / Vasos Sanguíneos / Neovascularización Fisiológica / Inhibidores de la Angiogénesis / Membrana Corioalantoides Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Microvasc Res Año: 2021 Tipo del documento: Article País de afiliación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Azatioprina / Vasos Sanguíneos / Neovascularización Fisiológica / Inhibidores de la Angiogénesis / Membrana Corioalantoides Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Microvasc Res Año: 2021 Tipo del documento: Article País de afiliación: Brasil