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Ex vivo microRNA and gene expression profiling of human Tr1-like cells suggests a role for miR-92a and -125a in the regulation of EOMES and IL-10R.
De Simone, Marco; Chirichella, Michele; Emming, Stefan; Mazzara, Saveria; Ranzani, Valeria; Gruarin, Paola; Moschetti, Giorgia; Pulvirenti, Nadia; Maglie, Stefano; Vasco, Chiara; Crosti, Maria Cristina; Rossetti, Grazisa; Pagani, Massimiliano; Abrignani, Sergio; Monticelli, Silvia; Geginat, Jens.
Afiliación
  • De Simone M; Istituto Nazionale Genetica Molecolare INGM 'Romeo ed Enrica Invernizzi', Milan, Italy.
  • Chirichella M; Institute for Research in Biomedicine (IRB), Università della Svizzera italiana (USI), Bellinzona, Switzerland.
  • Emming S; Institute for Research in Biomedicine (IRB), Università della Svizzera italiana (USI), Bellinzona, Switzerland.
  • Mazzara S; Istituto Nazionale Genetica Molecolare INGM 'Romeo ed Enrica Invernizzi', Milan, Italy.
  • Ranzani V; Istituto Nazionale Genetica Molecolare INGM 'Romeo ed Enrica Invernizzi', Milan, Italy.
  • Gruarin P; Istituto Nazionale Genetica Molecolare INGM 'Romeo ed Enrica Invernizzi', Milan, Italy.
  • Moschetti G; Istituto Nazionale Genetica Molecolare INGM 'Romeo ed Enrica Invernizzi', Milan, Italy.
  • Pulvirenti N; Istituto Nazionale Genetica Molecolare INGM 'Romeo ed Enrica Invernizzi', Milan, Italy.
  • Maglie S; Istituto Nazionale Genetica Molecolare INGM 'Romeo ed Enrica Invernizzi', Milan, Italy.
  • Vasco C; Istituto Nazionale Genetica Molecolare INGM 'Romeo ed Enrica Invernizzi', Milan, Italy.
  • Crosti MC; Istituto Nazionale Genetica Molecolare INGM 'Romeo ed Enrica Invernizzi', Milan, Italy.
  • Rossetti G; Istituto Nazionale Genetica Molecolare INGM 'Romeo ed Enrica Invernizzi', Milan, Italy.
  • Pagani M; FIRC Institute of Molecular Oncology (IFOM), Milan, Italy.
  • Abrignani S; Istituto Nazionale Genetica Molecolare INGM 'Romeo ed Enrica Invernizzi', Milan, Italy.
  • Monticelli S; FIRC Institute of Molecular Oncology (IFOM), Milan, Italy.
  • Geginat J; Department of Medical Biotechnology and Translational Medicine, Università degli Studi, Milano, Italy.
Eur J Immunol ; 51(12): 3243-3246, 2021 12.
Article en En | MEDLINE | ID: mdl-34528258
Ex vivo gene expression and miRNA profiling of Eomes+ Tr1-like cells suggested that they represent a differentiation stage that is intermediate between Th1-cells and cytotoxic CD4+ T-cells. Several microRNAs were downregulated in Eomes+ Tr1-like cells that might inhibit Tr1-cell differentiation. In particular, miR-92a targeted Eomes, while miR-125a inhibited IFN-g and IL-10R expression.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Células TH1 / Proteínas de Dominio T Box / Perfilación de la Expresión Génica / MicroARNs / Receptores de Interleucina-10 Límite: Humans Idioma: En Revista: Eur J Immunol Año: 2021 Tipo del documento: Article País de afiliación: Italia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Células TH1 / Proteínas de Dominio T Box / Perfilación de la Expresión Génica / MicroARNs / Receptores de Interleucina-10 Límite: Humans Idioma: En Revista: Eur J Immunol Año: 2021 Tipo del documento: Article País de afiliación: Italia