Electrophysiological biomarkers of behavioral dimensions from cross-species paradigms.
Transl Psychiatry
; 11(1): 482, 2021 09 17.
Article
en En
| MEDLINE
| ID: mdl-34535625
ABSTRACT
There has been a fundamental failure to translate preclinically supported research into clinically efficacious treatments for psychiatric disorders. One of the greatest impediments toward improving this species gap has been the difficulty of identifying translatable neurophysiological signals that are related to specific behavioral constructs. Here, we present evidence from three paradigms that were completed by humans and mice using analogous procedures, with each task eliciting candidate a priori defined electrophysiological signals underlying effortful motivation, reinforcement learning, and cognitive control. The effortful motivation was assessed using a progressive ratio breakpoint task, yielding a similar decrease in alpha-band activity over time in both species. Reinforcement learning was assessed via feedback in a probabilistic learning task with delta power significantly modulated by reward surprise in both species. Additionally, cognitive control was assessed in the five-choice continuous performance task, yielding response-locked theta power seen across species, and modulated by difficulty in humans. Together, these successes, and also the teachings from these failures, provide a roadmap towards the use of electrophysiology as a method for translating findings from the preclinical assays to the clinical settings.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Refuerzo en Psicología
/
Recompensa
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Transl Psychiatry
Año:
2021
Tipo del documento:
Article
País de afiliación:
Estados Unidos