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Voatriafricanines A and B, Trimeric Vobasine-Aspidosperma-Aspidosperma Alkaloids from Voacanga africana.
Fouotsa, Hugues; Le Pogam, Pierre; Mkounga, Pierre; Lannang, Alain Meli; Bernadat, Guillaume; Vanheuverzwijn, Jérôme; Zhou, Zhiyu; Leblanc, Karine; Rharrabti, Somia; Nkengfack, Augustin Ephrem; Gallard, Jean-François; Fontaine, Véronique; Meyer, Franck; Poupon, Erwan; Beniddir, Mehdi A.
Afiliación
  • Fouotsa H; Équipe "Chimie des Substances Naturelles" Université Paris-Saclay, CNRS, BioCIS, 5 Rue J.-B. Clément, 92290 Châtenay-Malabry, France.
  • Le Pogam P; Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
  • Mkounga P; Faculty of Pharmacy, Microbiology, Bioorganic and Macromolecular Chemistry Unit, Université Libre de Bruxelles, Campus de la Plaine-CP 206/04, Boulevard du Triomphe, ACC.2, PO Box 1050, 1050 Bruxelles, Belgium.
  • Lannang AM; Équipe "Chimie des Substances Naturelles" Université Paris-Saclay, CNRS, BioCIS, 5 Rue J.-B. Clément, 92290 Châtenay-Malabry, France.
  • Bernadat G; Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
  • Vanheuverzwijn J; Department of Chemistry, Higher Teachers Training College, University of Maroua, P.O. Box 55, Maroua, Cameroon.
  • Zhou Z; Équipe "Chimie des Substances Naturelles" Université Paris-Saclay, CNRS, BioCIS, 5 Rue J.-B. Clément, 92290 Châtenay-Malabry, France.
  • Leblanc K; Faculty of Pharmacy, Microbiology, Bioorganic and Macromolecular Chemistry Unit, Université Libre de Bruxelles, Campus de la Plaine-CP 206/04, Boulevard du Triomphe, ACC.2, PO Box 1050, 1050 Bruxelles, Belgium.
  • Rharrabti S; Faculty of Pharmacy, Microbiology, Bioorganic and Macromolecular Chemistry Unit, Université Libre de Bruxelles, Campus de la Plaine-CP 206/04, Boulevard du Triomphe, ACC.2, PO Box 1050, 1050 Bruxelles, Belgium.
  • Nkengfack AE; Équipe "Chimie des Substances Naturelles" Université Paris-Saclay, CNRS, BioCIS, 5 Rue J.-B. Clément, 92290 Châtenay-Malabry, France.
  • Gallard JF; Équipe "Chimie des Substances Naturelles" Université Paris-Saclay, CNRS, BioCIS, 5 Rue J.-B. Clément, 92290 Châtenay-Malabry, France.
  • Fontaine V; Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
  • Meyer F; Institut de Chimie des Substances Naturelles, CNRS, ICSN UPR 2301, Université Paris-Saclay, 91198 Gif-sur-Yvette, France.
  • Poupon E; Faculty of Pharmacy, Microbiology, Bioorganic and Macromolecular Chemistry Unit, Université Libre de Bruxelles, Campus de la Plaine-CP 206/04, Boulevard du Triomphe, ACC.2, PO Box 1050, 1050 Bruxelles, Belgium.
  • Beniddir MA; Faculty of Pharmacy, Microbiology, Bioorganic and Macromolecular Chemistry Unit, Université Libre de Bruxelles, Campus de la Plaine-CP 206/04, Boulevard du Triomphe, ACC.2, PO Box 1050, 1050 Bruxelles, Belgium.
J Nat Prod ; 84(10): 2755-2761, 2021 10 22.
Article en En | MEDLINE | ID: mdl-34569237
ABSTRACT
Voatriafricanines A and B (1 and 2), the first examples of vobasine-aspidosperma-aspidosperma monoterpene trisindole alkaloids, were isolated from the stem barks of Voacanga africana, guided by a molecular networking strategy. Their structures, including absolute configurations, were elucidated by spectroscopic methods and ECD calculations. Compounds 1 and 2 possess intramolecular hydrogen bonding, sufficiently robust to transfer homonuclear and heteronuclear magnetizations. Compound 1 exhibited potent antimycobacterial activity with no discernible cytotoxic activity.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Alcaloides Indólicos / Voacanga / Antibacterianos País/Región como asunto: Africa Idioma: En Revista: J Nat Prod Año: 2021 Tipo del documento: Article País de afiliación: Francia
Texto completo
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XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Alcaloides Indólicos / Voacanga / Antibacterianos País/Región como asunto: Africa Idioma: En Revista: J Nat Prod Año: 2021 Tipo del documento: Article País de afiliación: Francia