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Defining the Healthy Infant Metabolome: Liquid Chromatography Tandem-Mass Spectrometry Analysis of Dried Blood Spot Extracts from the Prospective Research on Early Determinants of Illness and Children's Health Trajectories Birth Cohort Study.
Schleif, William S; Harlan, Robert S; Hamblin, Frances; Amankwah, Ernest K; Goldenberg, Neil A; Hernandez, Raquel G; Johnson, Sara B; Reed, Shannon; Graham, David R.
Afiliación
  • Schleif WS; Johns Hopkins All Children's Pediatric Biorepository, Johns Hopkins All Children's Hospital, St Petersburg, FL; Pediatric Biospecimen Science Program, Johns Hopkins All Children's Institute for Clinical and Translational Research, St Petersburg, FL.
  • Harlan RS; Johns Hopkins Molecular Determinants Center and Core, Johns Hopkins All Children's Hospital, St Petersburg, FL; Johns Hopkins University School of Medicine, Baltimore, MD.
  • Hamblin F; Clinical Coordinating Center, Johns Hopkins All Children's Institute for Clinical and Translational Research, St Petersburg, FL.
  • Amankwah EK; Data Coordinating Center, Johns Hopkins All Children's Institute for Clinical and Translational Research, St Petersburg, FL; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Oncology, Johns Hopkins University School of Medicine, St Petersburg, FL.
  • Goldenberg NA; Pediatric Biospecimen Science Program, Johns Hopkins All Children's Institute for Clinical and Translational Research, St Petersburg, FL; Clinical Coordinating Center, Johns Hopkins All Children's Institute for Clinical and Translational Research, St Petersburg, FL; Data Coordinating Center, Johns H
  • Hernandez RG; Pediatric Health Equity Research Program, Johns Hopkins All Children's Institute for Clinical and Translational Research, St Petersburg, FL; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD.
  • Johnson SB; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.
  • Reed S; Johns Hopkins Molecular Determinants Center and Core, Johns Hopkins All Children's Hospital, St Petersburg, FL.
  • Graham DR; Pediatric Biospecimen Science Program, Johns Hopkins All Children's Institute for Clinical and Translational Research, St Petersburg, FL; Johns Hopkins Molecular Determinants Center and Core, Johns Hopkins All Children's Hospital, St Petersburg, FL; Department of Anesthesia and Critical Care Medicin
J Pediatr ; 241: 251-256.e4, 2022 02.
Article en En | MEDLINE | ID: mdl-34626671
ABSTRACT
Newborn screening using dried plasma spots offers preanalytical advantages over conventional cards for plasma-associated targets of interest. Herein we present dried plasma spot-based methods for measuring metabolites using a 250+ compound liquid chromatography tandem mass spectrometry library. Quality assurance reduced this library to 134, and from these, 30 compounds determined the normal newborn reference ranges.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Biomarcadores / Cromatografía Liquida / Tamizaje Neonatal / Espectrometría de Masas en Tándem / Metaboloma / Pruebas con Sangre Seca Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Female / Humans / Infant / Male / Newborn Idioma: En Revista: J Pediatr Año: 2022 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Biomarcadores / Cromatografía Liquida / Tamizaje Neonatal / Espectrometría de Masas en Tándem / Metaboloma / Pruebas con Sangre Seca Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Female / Humans / Infant / Male / Newborn Idioma: En Revista: J Pediatr Año: 2022 Tipo del documento: Article