Histone lactylation: epigenetic mark of glycolytic switch.

Dai, Xiaofeng; Lv, Xinyu; Thompson, Erik W; Ostrikov, Kostya Ken

Dai, Xiaofeng; Lv, Xinyu; Thompson, Erik W; Ostrikov, Kostya Ken.

Afiliación

Dai X; Wuxi School of Medicine, Jiangnan University, Wuxi 214122, China. Electronic address: xiaofeng.dai@jiangnan.edu.cn.
Lv X; Wuxi School of Medicine, Jiangnan University, Wuxi 214122, China.
Thompson EW; Queensland University of Technology, School of Biomedical Sciences, Faculty of Health, Brisbane 4059, Australia; Translational Research Institute, Woolloongabba, QLD 4102, Australia.
Ostrikov KK; Queensland University of Technology, School of Chemistry and Physics, Faculty of Science, Brisbane, QLD 4059, Australia.

Trends Genet ; 38(2): 124-127, 2022 02.

Article en En | MEDLINE | ID: mdl-34627643

RESUMEN

Histone lactylation and acetylation compete for epigenetic modification of lysines and mark the levels of lactates and acetyl-CoA. Whether pyruvate is committed to lactate or acetyl-CoA generation as the outlet of glycolysis determines cell fate towards malignancy or not. Taking control over the glycolytic switch as marked by lactylation suggests novel therapeutic opportunities against cancers.

Asunto(s)

Glucólisis; Histonas; Acetilcoenzima A/genética; Acetilcoenzima A/metabolismo; Acetilación; Epigénesis Genética; Glucólisis/genética; Histonas/genética; Histonas/metabolismo

Palabras clave

acetylation; epigenetic mark; glycolysis switch; lactylation

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Histonas / Glucólisis Idioma: En Revista: Trends Genet Asunto de la revista: GENETICA Año: 2022 Tipo del documento: Article

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