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Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors.
Bellail, Anita C; Jin, Hong Ri; Lo, Ho-Yin; Jung, Sung Han; Hamdouchi, Chafiq; Kim, Daeho; Higgins, Ryan K; Blanck, Maximilian; le Sage, Carlos; Cross, Benedict C S; Li, Jing; Mosley, Amber L; Wijeratne, Aruna B; Jiang, Wen; Ghosh, Manali; Zhao, Yin Quan; Hauck, Paula M; Shekhar, Anantha; Hao, Chunhai.
Afiliación
  • Bellail AC; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Jin HR; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN 46202, USA.
  • Lo HY; HB Therapeutics Inc., Indianapolis, IN 46202, USA.
  • Jung SH; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Hamdouchi C; Synovel Laboratory LLC, Danbury, CT 06811, USA.
  • Kim D; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Higgins RK; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Blanck M; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • le Sage C; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Cross BCS; Horizon Discovery, Cambridge, CB25 9TL, UK.
  • Li J; Horizon Discovery, Cambridge, CB25 9TL, UK.
  • Mosley AL; Horizon Discovery, Cambridge, CB25 9TL, UK.
  • Wijeratne AB; Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA.
  • Jiang W; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN 46202, USA.
  • Ghosh M; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Zhao YQ; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Hauck PM; Department of Biological Sciences, Markey Center for Structural Biology, Purdue University, West Lafayette, IN 47907, USA.
  • Shekhar A; Department of Biological Sciences, Markey Center for Structural Biology, Purdue University, West Lafayette, IN 47907, USA.
  • Hao C; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Sci Transl Med ; 13(615): eabh1486, 2021 Oct 13.
Article en En | MEDLINE | ID: mdl-34644148
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteína SUMO-1 / Neoplasias Límite: Animals / Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteína SUMO-1 / Neoplasias Límite: Animals / Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos