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Teladorsagia Circumcincta Galectin-Mucosal Interactome in Sheep.
Hafidi, Nur Nasuha; Swan, Jaclyn; Faou, Pierre; Lowe, Rohan; Rajapaksha, Harinda; Cairns, Callum; Stear, Michael; Beddoe, Travis.
Afiliación
  • Hafidi NN; Department of Animal, Plant and Soil Science and Centre for AgriBioscience (AgriBio), La Trobe University, Bundoora 3086, Australia.
  • Swan J; Centre for Livestock Interactions with Pathogens (CLiP), La Trobe University, Melbourne 3086, Australia.
  • Faou P; Department of Animal, Plant and Soil Science and Centre for AgriBioscience (AgriBio), La Trobe University, Bundoora 3086, Australia.
  • Lowe R; Centre for Livestock Interactions with Pathogens (CLiP), La Trobe University, Melbourne 3086, Australia.
  • Rajapaksha H; Department of Biochemistry & Genetics, La Trobe Institute for Molecular Science La Trobe University, Melbourne 3086, Australia.
  • Cairns C; Department of Biochemistry & Genetics, La Trobe Institute for Molecular Science La Trobe University, Melbourne 3086, Australia.
  • Stear M; Department of Biochemistry & Genetics, La Trobe Institute for Molecular Science La Trobe University, Melbourne 3086, Australia.
  • Beddoe T; Department of Animal, Plant and Soil Science and Centre for AgriBioscience (AgriBio), La Trobe University, Bundoora 3086, Australia.
Vet Sci ; 8(10)2021 Oct 04.
Article en En | MEDLINE | ID: mdl-34679046
Teladorsagia circumcincta is the most important gastrointestinal parasite in the livestock industry in temperate regions around the world, causing great economic losses. The infective third-stage larvae (L3) of Teladorsagia circumcincta secrete a large number of excretory-secretory (E/S) molecules, some of which are likely to play critical roles in modulating the host immune response. One of the most abundant E/S molecules is a protein termed Tci-gal-1, which has similarity to mammalian galectins. Galectins are a family of carbohydrate-binding molecules, with characteristic domain organisation and affinity for ß-galactosids that mediate a variety of important cellular functions including inflammation and immune responses. To understand the role of Tci-gal-1 at the host-parasite interface, we used a proteomics pull-down approach to identify Tc-gal-1 interacting proteins from sheep abomasal scrapes and whole tissue. A total of 135 unique proteins were identified from whole abomasal tissue samples, while 89 proteins were isolated from abomasal scrape samples. Of these proteins, 63 were present in both samples. Many of the host proteins identified, such as trefoil factors and mucin-like proteins, play critical roles in the host response. The identification of Tci-gal-1 binding partners provides new insights on host-parasite interactions and could lead to the development of new control strategies.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Vet Sci Año: 2021 Tipo del documento: Article País de afiliación: Australia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Vet Sci Año: 2021 Tipo del documento: Article País de afiliación: Australia