Inhibition of mevalonate metabolism by statins augments the immunoregulatory phenotype of vascular endothelial cells and inhibits the costimulation of CD4<sup>+</sup> T cells.

Agur, Timna; Wedel, Johannes; Bose, Sayantan; Sahankumari, A G Pramoda; Goodman, Daniel; Kong, Sek Won; Ghosh, Chandra C; Briscoe, David M

Inhibition of mevalonate metabolism by statins augments the immunoregulatory phenotype of vascular endothelial cells and inhibits the costimulation of CD4⁺ T cells.

Agur, Timna; Wedel, Johannes; Bose, Sayantan; Sahankumari, A G Pramoda; Goodman, Daniel; Kong, Sek Won; Ghosh, Chandra C; Briscoe, David M.

Afiliación

Agur T; The Transplant Research Program and the Division of Nephrology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.
Wedel J; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.
Bose S; The Transplant Research Program and the Division of Nephrology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.
Sahankumari AGP; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.
Goodman D; The Transplant Research Program and the Division of Nephrology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.
Kong SW; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.
Ghosh CC; The Transplant Research Program and the Division of Nephrology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.
Briscoe DM; The Transplant Research Program and the Division of Nephrology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.

Am J Transplant ; 22(3): 947-954, 2022 03.

Article en En | MEDLINE | ID: mdl-34687147

Asunto(s)

Inhibidores de Hidroximetilglutaril-CoA Reductasas; Linfocitos T CD4-Positivos/metabolismo; Células Cultivadas; Células Endoteliales; Inhibidores de Hidroximetilglutaril-CoA Reductasas/farmacología; Ácido Mevalónico/metabolismo; Ácido Mevalónico/farmacología; Fenotipo; Simvastatina/farmacología; Linfocitos T/metabolismo

Palabras clave

basic (laboratory) research/science; immune regulation; immunobiology; vascular biology

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Inhibidores de Hidroximetilglutaril-CoA Reductasas Idioma: En Revista: Am J Transplant Asunto de la revista: TRANSPLANTE Año: 2022 Tipo del documento: Article

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