Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme-ubiquitin complex.

St-Cyr, Daniel; Ceccarelli, Derek F; Orlicky, Stephen; van der Sloot, Almer M; Tang, Xiaojing; Kelso, Susan; Moore, Susan; James, Clint; Posternak, Ganna; Coulombe-Huntington, Jasmin; Bertomeu, Thierry; Marinier, Anne; Sicheri, Frank; Tyers, Mike

St-Cyr, Daniel; Ceccarelli, Derek F; Orlicky, Stephen; van der Sloot, Almer M; Tang, Xiaojing; Kelso, Susan; Moore, Susan; James, Clint; Posternak, Ganna; Coulombe-Huntington, Jasmin; Bertomeu, Thierry; Marinier, Anne; Sicheri, Frank; Tyers, Mike.

Afiliación

St-Cyr D; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Québec H3T 1J4, Canada.
Ceccarelli DF; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
Orlicky S; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
van der Sloot AM; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Québec H3T 1J4, Canada.
Tang X; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
Kelso S; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
Moore S; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
James C; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Québec H3T 1J4, Canada.
Posternak G; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Québec H3T 1J4, Canada.
Coulombe-Huntington J; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
Bertomeu T; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Québec H3T 1J4, Canada.
Marinier A; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Québec H3T 1J4, Canada.
Sicheri F; Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Québec H3T 1J4, Canada.
Tyers M; Department of Chemistry, University of Montreal, Montreal, Québec H3C 3J7, Canada.

Sci Adv ; 7(44): eabi5797, 2021 Oct 29.

Article en En | MEDLINE | ID: mdl-34705497

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Diagnostic_studies Idioma: En Revista: Sci Adv Año: 2021 Tipo del documento: Article País de afiliación: Canadá

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