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Discovery of MK-4688: an Efficient Inhibitor of the HDM2-p53 Protein-Protein Interaction.
Reutershan, Michael H; Machacek, Michelle R; Altman, Michael D; Bogen, Stephane; Cai, Mingmei; Cammarano, Carolyn; Chen, Dapeng; Christopher, Matthew; Cryan, John; Daublain, Pierre; Fradera, Xavier; Geda, Prasanthi; Goldenblatt, Peter; Hill, Armetta D; Kemper, Raymond A; Kutilek, Victoria; Li, Chaomin; Martinez, Michelle; McCoy, Mark; Nair, Latha; Pan, Weidong; Thompson, Christopher F; Scapin, Giovanna; Shizuka, Manami; Spatz, Marianne L; Steinhuebel, Dietrich; Sun, Binyuan; Voss, Matthew E; Wang, Xiao; Yang, Liping; Yeh, Tammie C; Dussault, Isabelle; Marshall, C Gary; Trotter, B Wesley.
Afiliación
  • Reutershan MH; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Machacek MR; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Altman MD; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Bogen S; Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, New Jersey 07032, United States.
  • Cai M; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Cammarano C; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Chen D; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Christopher M; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Cryan J; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Daublain P; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Fradera X; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Geda P; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Goldenblatt P; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Hill AD; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Kemper RA; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Kutilek V; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Li C; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Martinez M; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • McCoy M; Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, New Jersey 07032, United States.
  • Nair L; Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, New Jersey 07032, United States.
  • Pan W; Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, New Jersey 07032, United States.
  • Thompson CF; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Scapin G; Merck & Co., Inc., 2015 Galloping Hill Rd, Kenilworth, New Jersey 07032, United States.
  • Shizuka M; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Spatz ML; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Steinhuebel D; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Sun B; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Voss ME; Albany Molecular Research Inc., 61 Science Park Road, Singapore (West) 117525, Singapore.
  • Wang X; Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States.
  • Yang L; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Yeh TC; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Dussault I; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Marshall CG; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
  • Trotter BW; Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
J Med Chem ; 64(21): 16213-16241, 2021 11 11.
Article en En | MEDLINE | ID: mdl-34714078
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piridinas / Proteína p53 Supresora de Tumor / Proteínas Proto-Oncogénicas c-mdm2 / Imidazoles Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piridinas / Proteína p53 Supresora de Tumor / Proteínas Proto-Oncogénicas c-mdm2 / Imidazoles Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos