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Genome-wide association study identifies susceptibility loci for acute myeloid leukemia.
Lin, Wei-Yu; Fordham, Sarah E; Hungate, Eric; Sunter, Nicola J; Elstob, Claire; Xu, Yaobo; Park, Catherine; Quante, Anne; Strauch, Konstantin; Gieger, Christian; Skol, Andrew; Rahman, Thahira; Sucheston-Campbell, Lara; Wang, Junke; Hahn, Theresa; Clay-Gilmour, Alyssa I; Jones, Gail L; Marr, Helen J; Jackson, Graham H; Menne, Tobias; Collin, Mathew; Ivey, Adam; Hills, Robert K; Burnett, Alan K; Russell, Nigel H; Fitzgibbon, Jude; Larson, Richard A; Le Beau, Michelle M; Stock, Wendy; Heidenreich, Olaf; Alharbi, Abrar; Allsup, David J; Houlston, Richard S; Norden, Jean; Dickinson, Anne M; Douglas, Elisabeth; Lendrem, Clare; Daly, Ann K; Palm, Louise; Piechocki, Kim; Jeffries, Sally; Bornhäuser, Martin; Röllig, Christoph; Altmann, Heidi; Ruhnke, Leo; Kunadt, Desiree; Wagenführ, Lisa; Cordell, Heather J; Darlay, Rebecca; Andersen, Mette K.
Afiliación
  • Lin WY; Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
  • Fordham SE; Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
  • Hungate E; Section of Pediatric Hematology and Oncology, University of Chicago, Chicago, IL, USA.
  • Sunter NJ; Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
  • Elstob C; Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
  • Xu Y; Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
  • Park C; Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
  • Quante A; Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  • Strauch K; Ludwig-Maximilians-Universität München, Chair of Genetic Epidemiology, IBE, Faculty of Medicine, Munich, Germany.
  • Gieger C; Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  • Skol A; Ludwig-Maximilians-Universität München, Chair of Genetic Epidemiology, IBE, Faculty of Medicine, Munich, Germany.
  • Rahman T; Ludwig-Maximilians-Universität München, Chair of Genetic Epidemiology, IBE, Faculty of Medicine, Munich, Germany.
  • Sucheston-Campbell L; Section of Pediatric Hematology and Oncology, University of Chicago, Chicago, IL, USA.
  • Wang J; Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
  • Hahn T; College of Pharmacy, The Ohio State University, Columbus, OH, USA.
  • Clay-Gilmour AI; College of Pharmacy, The Ohio State University, Columbus, OH, USA.
  • Jones GL; Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA.
  • Marr HJ; Arnold School of Public Health, Department of Epidemiology & Biostatistics, University of South Carolina, Greenville, USA.
  • Jackson GH; Department of Haematology, Freeman Hospital, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, UK.
  • Menne T; Department of Haematology, Freeman Hospital, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, UK.
  • Collin M; Department of Haematology, Freeman Hospital, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, UK.
  • Ivey A; Department of Haematology, Freeman Hospital, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, UK.
  • Hills RK; Department of Haematology, Freeman Hospital, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, UK.
  • Burnett AK; Department of Medical and Molecular Genetics, King's College Medical School, London, UK.
  • Russell NH; Nuffield Department of Population Health, University of Oxford, Oxford, UK.
  • Fitzgibbon J; Paul O'Gorman Leukaemia Research Centre, University of Glasgow, Glasgow, UK.
  • Larson RA; Department of Haematology, Nottingham University Hospitals NHS Trust, Nottingham, UK.
  • Le Beau MM; Barts Cancer Institute, Queen Mary University of London, London, UK.
  • Stock W; Section of Pediatric Hematology and Oncology, University of Chicago, Chicago, IL, USA.
  • Heidenreich O; Section of Pediatric Hematology and Oncology, University of Chicago, Chicago, IL, USA.
  • Alharbi A; Section of Pediatric Hematology and Oncology, University of Chicago, Chicago, IL, USA.
  • Allsup DJ; Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
  • Houlston RS; Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
  • Norden J; Centre for Atherothrombosis and Metabolic Disease, Hull York Medical School, Hull, UK.
  • Dickinson AM; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
  • Douglas E; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
  • Lendrem C; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
  • Daly AK; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
  • Palm L; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
  • Piechocki K; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
  • Jeffries S; West Midlands Regional Genetics Laboratory, Birmingham Women's Hospital, Birmingham, UK.
  • Bornhäuser M; West Midlands Regional Genetics Laboratory, Birmingham Women's Hospital, Birmingham, UK.
  • Röllig C; West Midlands Regional Genetics Laboratory, Birmingham Women's Hospital, Birmingham, UK.
  • Altmann H; Department of Haematological Medicine, The Rayne Institute, King's College London, London, UK.
  • Ruhnke L; National Center for Tumor Diseases NCT, Partner site Dresden, Dresden, Germany.
  • Kunadt D; Medizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus Dresden, Technical University of Dresden, Dresden, Germany.
  • Wagenführ L; Medizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus Dresden, Technical University of Dresden, Dresden, Germany.
  • Cordell HJ; Medizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus Dresden, Technical University of Dresden, Dresden, Germany.
  • Darlay R; Medizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus Dresden, Technical University of Dresden, Dresden, Germany.
  • Andersen MK; Medizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus Dresden, Technical University of Dresden, Dresden, Germany.
Nat Commun ; 12(1): 6233, 2021 10 29.
Article en En | MEDLINE | ID: mdl-34716350
ABSTRACT
Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 × 10-8; KMT5B). We also identify a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N = 1287) at 6p21.32 (rs3916765; P = 1.51 × 10-10; HLA). Our results inform on AML etiology and identify putative functional genes operating in histone methylation (KMT5B) and immune function (HLA).
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Polimorfismo de Nucleótido Simple / Antígenos HLA Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans / Middle aged Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Polimorfismo de Nucleótido Simple / Antígenos HLA Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans / Middle aged Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article País de afiliación: Reino Unido