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Inclusion of the Inducible Caspase 9 Suicide Gene in CAR Construct Increases Safety of CAR.CD19 T Cell Therapy in B-Cell Malignancies.
Guercio, Marika; Manni, Simona; Boffa, Iolanda; Caruso, Simona; Di Cecca, Stefano; Sinibaldi, Matilde; Abbaszadeh, Zeinab; Camera, Antonio; Ciccone, Roselia; Polito, Vinicia Assunta; Ferrandino, Francesca; Reddel, Sofia; Catanoso, Maria Luigia; Bocceri, Emilia; Del Bufalo, Francesca; Algeri, Mattia; De Angelis, Biagio; Quintarelli, Concetta; Locatelli, Franco.
Afiliación
  • Guercio M; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Manni S; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Boffa I; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Caruso S; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Di Cecca S; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Sinibaldi M; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Abbaszadeh Z; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Camera A; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Ciccone R; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Polito VA; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Ferrandino F; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Reddel S; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Catanoso ML; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Bocceri E; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Del Bufalo F; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Algeri M; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • De Angelis B; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Quintarelli C; Department of Oncology-Haematology and Cell and Gene Therapy, Bambino Gesù Children Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy.
  • Locatelli F; Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Front Immunol ; 12: 755639, 2021.
Article en En | MEDLINE | ID: mdl-34737753

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Leucemia de Células B / Inmunoterapia Adoptiva / Linfoma de Células B / Genes Transgénicos Suicidas / Caspasa 9 / Receptores Quiméricos de Antígenos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Front Immunol Año: 2021 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Leucemia de Células B / Inmunoterapia Adoptiva / Linfoma de Células B / Genes Transgénicos Suicidas / Caspasa 9 / Receptores Quiméricos de Antígenos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Front Immunol Año: 2021 Tipo del documento: Article País de afiliación: Italia