Zanzibar yam (Dioscorea sansibarensis Pax) isolates exhibit cyclooxygenase enzyme and lipid peroxidation inhibitory activities.
Nat Prod Res
; 36(18): 4725-4729, 2022 Sep.
Article
en En
| MEDLINE
| ID: mdl-34781791
ABSTRACT
Several phenanthrenes (1-5), phenolics (6-8) and steroidal sapogenins (9-11) were isolated for the first time from the aqueous and methanolic extracts of Dioscorea sansibarensis Pax yam collected from Tanzania. Chemical structures of all the isolates (1-11) were determined by using 1D and 2D nuclear magnetic resonance spectral methods. All pure isolates were evaluated for anti-inflammatory activity using in vitro cyclooxygenase enzyme (COX-1 and -2) inhibitory assays. Among the isolates tested, phenanthrenes 3-5 showed the highest COX-1 and -2 enzyme inhibitory activity whereas phenolics (6-8) and steroidal sapogenins (9-11) exhibited moderate inhibition when compared to non-steroidal anti-inflammatory drugs aspirin, ibuprofen and naproxen. Compounds 6-11 were evaluated for antioxidant activity using lipid peroxidation inhibitory (LPO) assay for the first time and exhibited moderate LPO inhibition.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fenantrenos
/
Sapogeninas
/
Dioscorea
País/Región como asunto:
Africa
Idioma:
En
Revista:
Nat Prod Res
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos