The Dietary Inflammatory Index and hepatic health in the US adult population.
J Hum Nutr Diet
; 35(5): 968-979, 2022 10.
Article
en En
| MEDLINE
| ID: mdl-34783091
ABSTRACT
BACKGROUND:
There is limited evidence on the role of an anti-/pro-inflammatory diet in the prevention of non-alcoholic fatty liver disease (NAFLD). We aimed (i) to assess the anti-inflammatory diet profile and its association with transient elastography parameters, including liver stiffness measurement (LSM) and controlled attenuation parameter (CAP), and (ii) to analyse the relationship between the anti-inflammatory diet and surrogate markers of liver disease in a multiethnic US population.METHODS:
A cross-sectional study was conducted on a nationally representative population of 4189 US adults aged 20-80 years. A FibroScan® 502 V2 device (Echosens) was used to estimate the CAP and LSM. Liver markers, including the aspartate transaminase (AST) to alanine transaminase (ALT) ratio, fatty liver index (FLI) and fibrosis-4 score, were also calculated. The Dietary Inflammatory Index (DII) was calculated using a 24-h diet recall.RESULTS:
Lower DII scores (anti-inflammatory diet) were associated with a lower ASTALT ratio (p < 0.001) and FLI (p < 0.036) after adjusting for covariates. Linear regression analysis revealed that gamma-glutamyl transferase levels (ß = 1.702, 95% confidence interval [CI] = 0.325-3.080, p = 0.015), ALT levels (ß = -0.616, 95% CI = -1.097 to -0.135, p = 0.012), ASTALT ratio (ß = 0.025, 95% CI = 0.014-0.036, p < 0.001) and FLI (ß = 1.168, 95% CI = 0.224-2.112, p = 0.015) were significantly associated with the DII in the multivariable-adjusted model. Participants in the highest anti-inflammatory tertile had the lowest odds ratio (OR) for NAFLD assessed by FLI in both unadjusted (OR = 0.652, 95% CI = 0.539-0.788, p ≤ 0.001) and adjusted models (OR = 0.722, 95% CI = 0.537-0.972, p = 0.032). For the transient elastography parameters (LSM and CAP), no significant associations were identified.CONCLUSIONS:
There was no relationship between the transient elastography parameters and the anti-inflammatory diet profile, although our study showed an association between higher pro-inflammatory properties of diet and poorer hepatic health assessed by surrogate markers of liver disease. Therefore, strategies to promote an anti-inflammatory diet should be considered to prevent NAFLD in adults.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad del Hígado Graso no Alcohólico
Tipo de estudio:
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
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Risk_factors_studies
Límite:
Adult
/
Humans
Idioma:
En
Revista:
J Hum Nutr Diet
Asunto de la revista:
CIENCIAS DA NUTRICAO
Año:
2022
Tipo del documento:
Article
País de afiliación:
España