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Looking for Crumbs in the Obesity Forest: Anti-obesity Interventions and Obesity-Associated Cardiometabolic Traits in the Mexican Population. History and Systematic Review With Meta-Analyses.
Garcia-Oropesa, Esperanza M; Martinez-Lopez, Yoscelina E; Ruiz-Cejudo, Sonia María; Martínez-Ezquerro, José Darío; Diaz-Badillo, Alvaro; Ramirez-Pfeiffer, Carlos; Bustamante-Fuentes, Alejandra; Lopez-Sosa, Elena B; Moctezuma-Chavez, Oscar O; Nava-Gonzalez, Edna J; Perales-Torres, Adriana L; Perez-Navarro, Lucia M; Rosas-Diaz, Marisol; Carter, Kathleen; Tapia, Beatriz; Lopez-Alvarenga, Juan C.
Afiliación
  • Garcia-Oropesa EM; Laboratorio de Biología Molecular, Unidad Académica Multidisciplinaria Reynosa Aztlán (UAMRA), Universidad Autónoma de Tamaulipas, Reynosa, Mexico.
  • Martinez-Lopez YE; Programa de Doctorado en Ciencias Médicas y de la Salud, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico.
  • Ruiz-Cejudo SM; Unidad de Investigación Epidemiológica y en Servicios de Salud, Área Envejecimiento (UIESSAE), Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico.
  • Martínez-Ezquerro JD; Programa de Maestría y Doctorado en Música, Cognición Musical, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico.
  • Diaz-Badillo A; Unidad de Investigación Epidemiológica y en Servicios de Salud, Área Envejecimiento (UIESSAE), Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico.
  • Ramirez-Pfeiffer C; Centro de Ciencias de la Complejidad (C3), Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico.
  • Bustamante-Fuentes A; Department of Human Genetics, School of Medicine, The University of Texas Rio Grande Valley, Edinburg, TX, United States.
  • Lopez-Sosa EB; Programa de Maestría en Salud Pública, Universidad México-Americana del Norte (UMAN), Reynosa, Mexico.
  • Moctezuma-Chavez OO; Programa de Maestría en Salud Pública, Universidad México-Americana del Norte (UMAN), Reynosa, Mexico.
  • Nava-Gonzalez EJ; Escuela de Medicina, Universidad Panamericana, Mexico City, Mexico.
  • Perales-Torres AL; Cirugía General, Hospital Español, Mexico City, Mexico.
  • Perez-Navarro LM; Asociación Odontológica Mexicana para la Enseñanza y la Investigación, Mexico City, Mexico.
  • Rosas-Diaz M; Facultad de Salud Pública y Nutrición, Universidad Autónoma de Nuevo León, Monterrey, Mexico.
  • Carter K; Laboratorio de Bromatología, Unidad Académica Multidisciplinaria Reynosa Aztlán (UAMRA), Universidad Autónoma de Tamaulipas Reynosa-Aztlán, Reynosa, Mexico.
  • Tapia B; Servicio de Nefrología, Dirección de Investigación, Hospital General de México Dr. Eduardo Liceaga, Mexico City, Mexico.
  • Lopez-Alvarenga JC; Laboratorio de Biología Molecular, Unidad Académica Multidisciplinaria Reynosa Aztlán (UAMRA), Universidad Autónoma de Tamaulipas, Reynosa, Mexico.
Front Med (Lausanne) ; 8: 665023, 2021.
Article en En | MEDLINE | ID: mdl-34805192
Mexicans and Mexican Americans share culture, genetic background, and predisposition for chronic complications associated with obesity and diabetes making imperative efficacious treatments and prevention. Obesity has been treated for centuries focused-on weight loss while other treatments on associated conditions like gout, diabetes (T2D), and hypertriglyceridemia. To date, there is no systematic review that synthesizes the origin of obesity clinics in Mexico and the efforts to investigate treatments for obesity tested by randomized clinical trials (RCT). We conducted systematic searches in Pubmed, Scopus, and Web of Science to retrieve anti-obesity RCT through 2019 and without an inferior temporal limit. The systematic review included RCT of anti-obesity treatments in the Mexican adult population, covering alternative medicine, pharmacological, nutritional, behavioral, and surgical interventions reporting metabolism-associated traits such as BMI, weight, waist circumference, triglycerides, glucose, among others. Only the studies with at least 3 months of treatment were included in the meta-analyses in order to reduce placebo effects. We found 634 entries, after removal of duplicates and screening the studies based on eligibility criteria, we analyzed 43 national, and 2 multinational-collaborative studies. Most of the national studies had small sample sizes, and the implemented strategies do not have replications in the population. The nutrition/behavioral interventions were difficult to blind, and most studies have medium-to-high risk of bias. Nutritional/behavioral interventions and medications showed effects on BMI, waist circumference, and blood pressure. Simple measures like pure water instead of sweet beverages decrease triglycerides and systolic blood pressure. Dark chocolate showed the highest effect for BMI and high blood pressure, and treatment with insulin increased weight in those with T2D. The study of obesity in Mexico has been on-going for more than four decades, the interest on RCT just increased until this millennium, but with small sample sizes and lack of replication. The interventions affect different cardiometabolic associated traits, which should be analyzed in detail in the population living near the Mexico-U.S. border; therefore, bi-national collaboration is desirable to disentangle the cultural effects on this population's treatment response. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020221436, identifier: CRD42020221436.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Clinical_trials / Prognostic_studies / Risk_factors_studies / Systematic_reviews País/Región como asunto: Mexico Idioma: En Revista: Front Med (Lausanne) Año: 2021 Tipo del documento: Article País de afiliación: México

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Clinical_trials / Prognostic_studies / Risk_factors_studies / Systematic_reviews País/Región como asunto: Mexico Idioma: En Revista: Front Med (Lausanne) Año: 2021 Tipo del documento: Article País de afiliación: México