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Epidemiological and Immunological Features of Obesity and SARS-CoV-2.
Nilles, Eric J; Siddiqui, Sameed M; Fischinger, Stephanie; Bartsch, Yannic C; de St Aubin, Michael; Zhou, Guohai; Gluck, Matthew J; Berger, Samuel; Rhee, Justin; Petersen, Eric; Mormann, Benjamin; Loesche, Michael; Hu, Yiyuan; Chen, Zhilin; Yu, Jingyou; Gebre, Makda; Atyeo, Caroline; Gorman, Matthew J; Zhu, Alex Lee; Burke, John; Slein, Matthew; Hasdianda, Mohammad A; Jambaulikar, Guruprasad; Boyer, Edward W; Sabeti, Pardis C; Barouch, Dan H; Julg, Boris; Kucharski, Adam J; Musk, Elon R; Lauffenburger, Douglas A; Alter, Galit; Menon, Anil S.
Afiliación
  • Nilles EJ; Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Siddiqui SM; Harvard Medical School, Boston, MA 02115, USA.
  • Fischinger S; Harvard Humanitarian Initiative, Boston, MA 02114, USA.
  • Bartsch YC; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02115, USA.
  • de St Aubin M; Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  • Zhou G; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Gluck MJ; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Berger S; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Rhee J; Harvard Humanitarian Initiative, Boston, MA 02114, USA.
  • Petersen E; Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Mormann B; Harvard Medical School, Boston, MA 02115, USA.
  • Loesche M; Space Exploration Technologies Corp., Hawthorne, CA 90250, USA.
  • Hu Y; Space Exploration Technologies Corp., Hawthorne, CA 90250, USA.
  • Chen Z; Space Exploration Technologies Corp., Hawthorne, CA 90250, USA.
  • Yu J; Space Exploration Technologies Corp., Hawthorne, CA 90250, USA.
  • Gebre M; Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Atyeo C; Space Exploration Technologies Corp., Hawthorne, CA 90250, USA.
  • Gorman MJ; Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Zhu AL; Space Exploration Technologies Corp., Hawthorne, CA 90250, USA.
  • Burke J; Space Exploration Technologies Corp., Hawthorne, CA 90250, USA.
  • Slein M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Hasdianda MA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Jambaulikar G; Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
  • Boyer EW; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Sabeti PC; Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
  • Barouch DH; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Julg B; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Kucharski AJ; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Musk ER; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Lauffenburger DA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Alter G; Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Menon AS; Harvard Medical School, Boston, MA 02115, USA.
Viruses ; 13(11)2021 11 06.
Article en En | MEDLINE | ID: mdl-34835041
ABSTRACT
Obesity is a key correlate of severe SARS-CoV-2 outcomes while the role of obesity on risk of SARS-CoV-2 infection, symptom phenotype, and immune response remain poorly defined. We examined data from a prospective SARS-CoV-2 cohort study to address these questions. Serostatus, body mass index, demographics, comorbidities, and prior COVID-19 compatible symptoms were assessed at baseline and serostatus and symptoms monthly thereafter. SARS-CoV-2 immunoassays included an IgG ELISA targeting the spike RBD, multiarray Luminex targeting 20 viral antigens, pseudovirus neutralization, and T cell ELISPOT assays. Our results from a large prospective SARS-CoV-2 cohort study indicate symptom phenotype is strongly influenced by obesity among younger but not older age groups; we did not identify evidence to suggest obese individuals are at higher risk of SARS-CoV-2 infection; and remarkably homogenous immune activity across BMI categories suggests immune protection across these groups may be similar.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Glicoproteína de la Espiga del Coronavirus / COVID-19 / Anticuerpos Antivirales / Obesidad Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Viruses Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Glicoproteína de la Espiga del Coronavirus / COVID-19 / Anticuerpos Antivirales / Obesidad Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Viruses Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos