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Dexmedetomidine Clearance Decreases with Increasing Drug Exposure: Implications for Current Dosing Regimens and Target-controlled Infusion Models Assuming Linear Pharmacokinetics.
Alvarez-Jimenez, Ricardo; Weerink, Maud A S; Hannivoort, Laura N; Su, Hong; Struys, Michel M R F; Loer, Stephan A; Colin, Pieter J.
Afiliación
  • Alvarez-Jimenez R; Department of Anesthesiology, Amsterdam University Medical Center, Amsterdam, The Netherlands.
  • Weerink MAS; the Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Hannivoort LN; the Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Su H; the Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Struys MMRF; the Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; the Department of Basic and Applied Medical Sciences, Ghent University, Ghent, Belgium.
  • Loer SA; Department of Anesthesiology, Amsterdam University Medical Center, Amsterdam, The Netherlands.
  • Colin PJ; the Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Anesthesiology ; 136(2): 279-292, 2022 02 01.
Article en En | MEDLINE | ID: mdl-34851425

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tasa de Depuración Metabólica / Sistemas de Liberación de Medicamentos / Dinámicas no Lineales / Dexmedetomidina / Modelos Biológicos Tipo de estudio: Guideline / Prognostic_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Anesthesiology Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tasa de Depuración Metabólica / Sistemas de Liberación de Medicamentos / Dinámicas no Lineales / Dexmedetomidina / Modelos Biológicos Tipo de estudio: Guideline / Prognostic_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Anesthesiology Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos