&#945;-Lipoic Acid Has the Potential to Normalize Copper Metabolism, Which Is Dysregulated in Alzheimer's Disease.

Metsla, Kristel; Kirss, Sigrid; Laks, Katrina; Sildnik, Gertrud; Palgi, Mari; Palumaa, Teele; Tõugu, Vello; Palumaa, Peep

α-Lipoic Acid Has the Potential to Normalize Copper Metabolism, Which Is Dysregulated in Alzheimer's Disease.

Metsla, Kristel; Kirss, Sigrid; Laks, Katrina; Sildnik, Gertrud; Palgi, Mari; Palumaa, Teele; Tõugu, Vello; Palumaa, Peep.

Afiliación

Metsla K; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia.
Kirss S; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia.
Laks K; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia.
Sildnik G; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia.
Palgi M; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia.
Palumaa T; East Tallinn Central Hospital Eye Clinic, Tallinn, Estonia.
Tõugu V; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia.
Palumaa P; Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia.

J Alzheimers Dis ; 85(2): 715-728, 2022.

Article en En | MEDLINE | ID: mdl-34864665

Asunto(s)

Enfermedad de Alzheimer/metabolismo; Cobre/metabolismo; Neuronas/metabolismo; Ácido Tióctico/farmacología; Enfermedad de Alzheimer/genética; Secretasas de la Proteína Precursora del Amiloide/genética; Secretasas de la Proteína Precursora del Amiloide/metabolismo; Péptidos beta-Amiloides/genética; Péptidos beta-Amiloides/metabolismo; Precursor de Proteína beta-Amiloide/genética; Precursor de Proteína beta-Amiloide/metabolismo; Animales; Ácido Aspártico Endopeptidasas/genética; Ácido Aspártico Endopeptidasas/metabolismo; Encéfalo/metabolismo; Encéfalo/patología; Línea Celular; Modelos Animales de Enfermedad; Drosophila melanogaster; Humanos

Palabras clave

Alzheimer's disease; copper metabolism; metalloneurochemistry; α-lipoic acid

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ácido Tióctico / Cobre / Enfermedad de Alzheimer / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estonia

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