Therapeutic Interventions Targeting Innate Immune Receptors: A Balancing Act.
Chem Rev
; 122(3): 3414-3458, 2022 02 09.
Article
en En
| MEDLINE
| ID: mdl-34870969
ABSTRACT
The innate immune system is an organism's first line of defense against an onslaught of internal and external threats. The downstream adaptive immune system has been a popular target for therapeutic intervention, while there is a relative paucity of therapeutics targeting the innate immune system. However, the innate immune system plays a critical role in many human diseases, such as microbial infection, cancer, and autoimmunity, highlighting the need for ongoing therapeutic research. In this review, we discuss the major innate immune pathways and detail the molecular strategies underpinning successful therapeutics targeting each pathway as well as previous and ongoing efforts. We will also discuss any recent discoveries that could inform the development of novel therapeutic strategies. As our understanding of the innate immune system continues to develop, we envision that therapies harnessing the power of the innate immune system will become the mainstay of treatment for a wide variety of human diseases.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Inmunidad Innata
Límite:
Humans
Idioma:
En
Revista:
Chem Rev
Año:
2022
Tipo del documento:
Article