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Risk of Alzheimer's disease and related dementia by sex and race/ethnicity: The Multiethnic Cohort Study.
Lim, Unhee; Wang, Songren; Park, Song-Yi; Bogumil, David; Wu, Anna H; Cheng, Iona; Haiman, Christopher A; Le Marchand, Loïc; Wilkens, Lynne R; White, Lon; Setiawan, V Wendy.
Afiliación
  • Lim U; Cancer Epidemiology Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, Hawaii, USA.
  • Wang S; Department of Population and Public Health Sciences, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
  • Park SY; Cancer Epidemiology Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, Hawaii, USA.
  • Bogumil D; Department of Population and Public Health Sciences, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
  • Wu AH; Department of Population and Public Health Sciences, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
  • Cheng I; Department of Epidemiology and Biostatistics, University of California, San Francisco, California, USA.
  • Haiman CA; Department of Population and Public Health Sciences, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
  • Le Marchand L; Cancer Epidemiology Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, Hawaii, USA.
  • Wilkens LR; Cancer Epidemiology Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, Hawaii, USA.
  • White L; Pacific Health Research and Education Institute, Honolulu, Hawaii, USA.
  • Setiawan VW; John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA.
Alzheimers Dement ; 18(9): 1625-1634, 2022 09.
Article en En | MEDLINE | ID: mdl-34882963
ABSTRACT

INTRODUCTION:

Data are limited for comparison of sex- and race/ethnicity-specific risks of Alzheimer's disease and related dementia (ADRD).

METHODS:

In the population-based Multiethnic Cohort, we estimated the age-standardized diagnostic incidence rate (ASDIR) and relative risk of late-onset ADRD (n = 16,410) among 105,796 participants based on Medicare claims (1999-2014) by sex and race/ethnicity.

RESULTS:

The ASDIR for ADRD was higher for women (17.0 per 1000 person-years) than for men (15.3) and varied across African Americans (22.9 in women, 21.5 in men), Native Hawaiians (19.3, 19.4), Latinos (16.8, 14.7), Whites (16.4, 15.5), Japanese Americans (14.8, 13.8), and Filipinos (12.5, 9.7). Similar risk patterns were observed for AD. Adjustment for education and cardiometabolic diseases attenuated the differences. Accounting for deaths from competing causes increased the sex difference, while reducing the racial/ethnic differences. Less racial/ethnic disparity was detected among apolipoprotein E (APOE) e4 carriers.

DISCUSSION:

More research is needed to understand the sex and racial/ethnic differences in ADRD.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Etnicidad / Enfermedad de Alzheimer Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male País/Región como asunto: America do norte Idioma: En Revista: Alzheimers Dement Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Etnicidad / Enfermedad de Alzheimer Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male País/Región como asunto: America do norte Idioma: En Revista: Alzheimers Dement Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos