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Alterations in sphingolipid composition and mitochondrial bioenergetics represent synergistic therapeutic vulnerabilities linked to multidrug resistance in leukemia.
Fisher-Wellman, Kelsey H; Hagen, James T; Kassai, Miki; Kao, Li-Pin; Nelson, Margaret A M; McLaughlin, Kelsey L; Coalson, Hannah S; Fox, Todd E; Tan, Su-Fern; Feith, David J; Kester, Mark; Loughran, Thomas P; Claxton, David F; Cabot, Myles C.
Afiliación
  • Fisher-Wellman KH; Department of Physiology, Brody School of Medicine, and the East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA.
  • Hagen JT; Department of Physiology, Brody School of Medicine, and the East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA.
  • Kassai M; Department of Biochemistry & Molecular Biology, Brody School of Medicine, and the East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA.
  • Kao LP; Department of Biochemistry & Molecular Biology, Brody School of Medicine, and the East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA.
  • Nelson MAM; Department of Physiology, Brody School of Medicine, and the East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA.
  • McLaughlin KL; Department of Physiology, Brody School of Medicine, and the East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA.
  • Coalson HS; Department of Physiology, Brody School of Medicine, and the East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, North Carolina, USA.
  • Fox TE; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
  • Tan SF; Department of Medicine, Hematology/Oncology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
  • Feith DJ; Department of Medicine, Hematology/Oncology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
  • Kester M; University of Virginia Cancer Center, Charlottesville, Virginia, USA.
  • Loughran TP; Department of Medicine, Hematology/Oncology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
  • Claxton DF; University of Virginia Cancer Center, Charlottesville, Virginia, USA.
  • Cabot MC; Department of Medicine, Hematology/Oncology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
FASEB J ; 36(1): e22094, 2022 01.
Article en En | MEDLINE | ID: mdl-34888943
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fosforilación Oxidativa / Esfingolípidos / Leucemia / Resistencia a Múltiples Medicamentos / Resistencia a Antineoplásicos / Mitocondrias Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fosforilación Oxidativa / Esfingolípidos / Leucemia / Resistencia a Múltiples Medicamentos / Resistencia a Antineoplásicos / Mitocondrias Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos