Functional and structural characterization of a GH3 ß-N-acetylhexosaminidase from Akkermansia muciniphila involved in mucin degradation.

Qian, Kaiyue; Yang, Wenyi; Chen, Xiaolei; Wang, Yongzhong; Zhang, Min; Wang, Mingzhu

Qian, Kaiyue; Yang, Wenyi; Chen, Xiaolei; Wang, Yongzhong; Zhang, Min; Wang, Mingzhu.

Afiliación

Qian K; School of Life Sciences, Anhui University, Hefei, Anhui, 230601, China; Key Laboratory of Human Microenvironment and Precision Medicine of Anhui Higher Education Institutes, Anhui University, Hefei, Anhui, 230601, China.
Yang W; School of Life Sciences, Anhui University, Hefei, Anhui, 230601, China; Key Laboratory of Human Microenvironment and Precision Medicine of Anhui Higher Education Institutes, Anhui University, Hefei, Anhui, 230601, China.
Chen X; Institutes of Physical Science and Information Technology, Anhui University, Hefei, Anhui, 230601, China.
Wang Y; School of Life Sciences, Anhui University, Hefei, Anhui, 230601, China; Key Laboratory of Human Microenvironment and Precision Medicine of Anhui Higher Education Institutes, Anhui University, Hefei, Anhui, 230601, China.
Zhang M; School of Life Sciences, Anhui University, Hefei, Anhui, 230601, China; Key Laboratory of Human Microenvironment and Precision Medicine of Anhui Higher Education Institutes, Anhui University, Hefei, Anhui, 230601, China. Electronic address: zhmin07@ahu.edu.cn.
Wang M; School of Life Sciences, Anhui University, Hefei, Anhui, 230601, China; Key Laboratory of Human Microenvironment and Precision Medicine of Anhui Higher Education Institutes, Anhui University, Hefei, Anhui, 230601, China; Institutes of Physical Science and Information Technology, Anhui University, He

Biochem Biophys Res Commun ; 589: 186-191, 2022 01 22.

Article en En | MEDLINE | ID: mdl-34922201

Asunto(s)

Mucinas/metabolismo; beta-N-Acetilhexosaminidasas/química; beta-N-Acetilhexosaminidasas/metabolismo; Acetilglucosamina/metabolismo; Akkermansia/enzimología; Modelos Moleculares; Homología Estructural de Proteína; Relación Estructura-Actividad; Especificidad por Sustrato

Palabras clave

Akkermansia muciniphila; Catalytic mechanism; Crystal structure; Glycoside hydrolase 3; ß-N-acetylhexosaminidases

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Beta-N-Acetilhexosaminidasas / Mucinas Idioma: En Revista: Biochem Biophys Res Commun Año: 2022 Tipo del documento: Article País de afiliación: China

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