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Central nervous system regeneration.
Varadarajan, Supraja G; Hunyara, John L; Hamilton, Natalie R; Kolodkin, Alex L; Huberman, Andrew D.
Afiliación
  • Varadarajan SG; Department of Neurobiology, Stanford University, Stanford, CA 94305, USA.
  • Hunyara JL; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Hamilton NR; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
  • Kolodkin AL; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: kolodkin@jhmi.edu.
  • Huberman AD; Department of Neurobiology, Stanford University, Stanford, CA 94305, USA; Department of Ophthalmology, Stanford University, Stanford, CA 94305, USA. Electronic address: adh1@stanford.edu.
Cell ; 185(1): 77-94, 2022 01 06.
Article en En | MEDLINE | ID: mdl-34995518
Neurons of the mammalian central nervous system fail to regenerate. Substantial progress has been made toward identifying the cellular and molecular mechanisms that underlie regenerative failure and how altering those pathways can promote cell survival and/or axon regeneration. Here, we summarize those findings while comparing the regenerative process in the central versus the peripheral nervous system. We also highlight studies that advance our understanding of the mechanisms underlying neural degeneration in response to injury, as many of these mechanisms represent primary targets for restoring functional neural circuits.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Axones / Transducción de Señal / Sistema Nervioso Central / Regeneración Nerviosa / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Cell Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Axones / Transducción de Señal / Sistema Nervioso Central / Regeneración Nerviosa / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Cell Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos