Downregulation of the farnesoid X receptor promotes colorectal tumorigenesis by facilitating enterotoxigenic Bacteroides fragilis colonization.

Guo, Suhang; Peng, Yi; Lou, Yan; Cao, Lijuan; Liu, Junqing; Lin, Nengming; Cai, Sheng; Kang, Yu; Zeng, Su; Yu, Lushan

Guo, Suhang; Peng, Yi; Lou, Yan; Cao, Lijuan; Liu, Junqing; Lin, Nengming; Cai, Sheng; Kang, Yu; Zeng, Su; Yu, Lushan.

Afiliación

Guo S; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Peng Y; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Lou Y; Departments of Pharmacy, The First Affiliated Hospital and Intensive Care Unit, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Cao L; State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism, China Pharmaceutical University, Nanjing 210009, China.
Liu J; Radiation Oncology, The First Affiliated Hospital and Intensive Care Unit, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Lin N; Department of Clinical Pharmacy, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Cai S; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Kang Y; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Zeng S; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Yu L; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Department of Clinical Pharmacy, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's

Pharmacol Res ; 177: 106101, 2022 03.

Article en En | MEDLINE | ID: mdl-35104632

Asunto(s)

Infecciones Bacterianas; Neoplasias Colorrectales; Animales; Bacteroides fragilis/metabolismo; Ácidos y Sales Biliares/metabolismo; Carcinogénesis; Transformación Celular Neoplásica; Regulación hacia Abajo; Humanos; Inmunoglobulina A Secretora/metabolismo; Ratones

Palabras clave

Azoxymethane (PubChem CID: 33184); Bile acids; Chenodeoxycholic acid (PubChem CID: 10133); Cholestyramine (PubChem CID: 137699107); Cholic acid (PubChem CID: 221493); Colorectal cancer; Deoxycholic acid (PubChem CID: 222528); Enterotoxigenic Bacteroides fragilis; Farnesoid X receptor; Glycodeoxycholic acid (PubChem CID: 3035026); Gut microbiota; Lithocholic acid (PubChem CID: 9903); Obeticholic acid (PubChem CID: 447715); Secretory immunoglobulin A; Tauro-ß-muricholic acid (PubChem CID: 21124703); Taurocholic acid (PubChem CID: 6675); Tauroursodeoxycholic acid (PubChem CID: 9848818)

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones Bacterianas / Neoplasias Colorrectales Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China

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