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Acute Neurotoxicity of Antisense Oligonucleotides After Intracerebroventricular Injection Into Mouse Brain Can Be Predicted from Sequence Features.
Hagedorn, Peter H; Brown, Jeffrey M; Easton, Amy; Pierdomenico, Maria; Jones, Kelli; Olson, Richard E; Mercer, Stephen E; Li, Dong; Loy, James; Høg, Anja M; Jensen, Marianne L; Gill, Martin; Cacace, Angela M.
Afiliación
  • Hagedorn PH; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Copenhagen, Hørsholm, Denmark.
  • Brown JM; Bristol Myers Squibb Research and Development, Princeton, New Jersey, USA.
  • Easton A; Bristol Myers Squibb Research and Development, Princeton, New Jersey, USA.
  • Pierdomenico M; Bristol Myers Squibb Research and Development, Princeton, New Jersey, USA.
  • Jones K; Bristol Myers Squibb Research and Development, Princeton, New Jersey, USA.
  • Olson RE; Bristol Myers Squibb Research and Development, Princeton, New Jersey, USA.
  • Mercer SE; Bristol Myers Squibb Research and Development, Princeton, New Jersey, USA.
  • Li D; Bristol Myers Squibb Research and Development, Princeton, New Jersey, USA.
  • Loy J; Bristol Myers Squibb Research and Development, Princeton, New Jersey, USA.
  • Høg AM; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Copenhagen, Hørsholm, Denmark.
  • Jensen ML; Roche Pharma Research and Early Development, Therapeutic Modalities, Roche Innovation Center Copenhagen, Hørsholm, Denmark.
  • Gill M; Bristol Myers Squibb Research and Development, Princeton, New Jersey, USA.
  • Cacace AM; Bristol Myers Squibb Research and Development, Princeton, New Jersey, USA.
Nucleic Acid Ther ; 32(3): 151-162, 2022 06.
Article en En | MEDLINE | ID: mdl-35166597
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oligonucleótidos Antisentido / Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Nucleic Acid Ther Año: 2022 Tipo del documento: Article País de afiliación: Dinamarca
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Oligonucleótidos Antisentido / Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Nucleic Acid Ther Año: 2022 Tipo del documento: Article País de afiliación: Dinamarca