Cryoprotective agents influence viral dosage and thermal stability of inhalable dry powder vaccines.

Manser, Myla; Feng, Xueya; Xing, Zhou; Cranston, Emily D; Thompson, Michael R

Manser, Myla; Feng, Xueya; Xing, Zhou; Cranston, Emily D; Thompson, Michael R.

Afiliación

Manser M; Department of Chemical Engineering, McMaster University, Hamilton, Ontario L8S 4L7, Canada.
Feng X; McMaster Immunology Research Centre and Department of Medicine, McMaster University, Hamilton, Ontario L8S 4L7, Canada.
Xing Z; McMaster Immunology Research Centre and Department of Medicine, McMaster University, Hamilton, Ontario L8S 4L7, Canada.
Cranston ED; Department of Chemical Engineering, McMaster University, Hamilton, Ontario L8S 4L7, Canada; Department of Wood Science, University of British Columbia, 2424 Main Mall, Vancouver, BC V6T 1Z4, Canada; Department of Chemical and Biological Engineering, University of British Columbia, 2360 East Mall, Va
Thompson MR; Department of Chemical Engineering, McMaster University, Hamilton, Ontario L8S 4L7, Canada. Electronic address: mthomps@mcmaster.ca.

Int J Pharm ; 617: 121602, 2022 Apr 05.

Article en En | MEDLINE | ID: mdl-35189314

Asunto(s)

Crioprotectores; Vacunas; Administración por Inhalación; Aerosoles; Inhaladores de Polvo Seco; Humanos; Manitol; Tamaño de la Partícula; Polvos; Trehalosa

Palabras clave

Adenovirus; Cryoprotective agent; Glycerol; Inhalation; Spray drying; Thermal stability

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Vacunas / Crioprotectores Límite: Humans Idioma: En Revista: Int J Pharm Año: 2022 Tipo del documento: Article País de afiliación: Canadá

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