Reversed Apico-Basal Myocardial Relaxation Sequence During Exercise in Long QT Syndrome Mutations Carriers With History of Previous Cardiac Events.
Front Physiol
; 12: 780448, 2021.
Article
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| MEDLINE
| ID: mdl-35197859
ABSTRACT
BACKGROUND:
Recent echocardiography studies in inherited long QT syndrome (LQTS) have shown left ventricular (LV) myocardial relaxation disturbances to follow markedly prolonged and dispersed mechanical contraction.AIM:
We used speckle-tracking echocardiography to assess disturbances in LV myocardial relaxation sequence during exercise and their relationship to symptoms.METHODS:
Forty seven LQTS patients (45 ± 15 years, 25 female and 20 symptomatic, LVEF 65 ± 6%) and 35 controls underwent exercise echocardiogram using Bruce protocol. ECG and echo parameters were recorded at rest, peak exercise (p.e.) and recovery.RESULTS:
Between patients and controls there were no differences in age, gender, HR or LVEF. At p.e, patients had longer time to LV longitudinal ESR (tESR) at all three LV segments; basal (p < 0.0001), mid- cavity (p = 0.03) and apical (p = 0.03) whereas at rest such difference was noted only at base (p = 0.0007). Patients showed reversed apico-basal relaxation sequence (ΔtESRbase-apex) with early relaxation onset occurring later at base than at apex, both at rest (49 ± 43 vs. -29 ± 19 ms, p < 0.0001) and at p.e. (46 ± 38 vs. -40 ± 22 ms, p < 0.0001), particularly in symptomatic patients (69 ± 44 vs. 32 ± 26, p < 0.0007). ΔtESRbase-apex correlated with longer QTc interval, lower ESR and attenuated LV stroke volume.CONCLUSION:
LQTS patients show reversed longitudinal relaxation sequence, which worsens with exercise, particularly in those with previous cardiac events.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Front Physiol
Año:
2021
Tipo del documento:
Article
País de afiliación:
Suecia