Sodium-containing acetaminophen and cardiovascular outcomes in individuals with and without hypertension.
Eur Heart J
; 43(18): 1743-1755, 2022 05 07.
Article
en En
| MEDLINE
| ID: mdl-35201347
ABSTRACT
AIMS:
Previous studies have found high sodium intake to be associated with increased risks of cardiovascular disease (CVD) and all-cause mortality among individuals with hypertension; findings on the effect of intake among individuals without hypertension have been equivocal. We aimed to compare the risks of incident CVD and all-cause mortality among initiators of sodium-containing acetaminophen with the risk of initiators of non-sodium-containing formulations of the same drug according to the history of hypertension. METHODS ANDRESULTS:
Using The Health Improvement Network, we conducted two cohort studies among individuals with and without hypertension. We examined the relation of sodium-containing acetaminophen to the risk of each outcome during 1-year follow-up using marginal structural models with an inverse probability weighting to adjust for time-varying confounders. The outcomes were incident CVD (myocardial infarction, stroke, and heart failure) and all-cause mortality. Among individuals with hypertension (mean age 73.4 years), 122 CVDs occurred among 4532 initiators of sodium-containing acetaminophen (1-year risk 5.6%) and 3051 among 146 866 non-sodium-containing acetaminophen initiators (1-year risk 4.6%). The average weighted hazard ratio (HR) was 1.59 [95% confidence interval (CI) 1.32-1.92]. Among individuals without hypertension (mean age 71.0 years), 105 CVDs occurred among 5351 initiators of sodium-containing acetaminophen (1-year risk 4.4%) and 2079 among 141 948 non-sodium-containing acetaminophen initiators (1-year risk 3.7%), with an average weighted HR of 1.45 (95% CI 1.18-1.79). Results of specific CVD outcomes and all-cause mortality were similar.CONCLUSION:
The initiation of sodium-containing acetaminophen was associated with increased risks of CVD and all-cause mortality among individuals with or without hypertension. Our findings suggest that individuals should avoid unnecessary excessive sodium intake through sodium-containing acetaminophen use.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Sodio en la Dieta
/
Enfermedades Cardiovasculares
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Hipertensión
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Infarto del Miocardio
Tipo de estudio:
Etiology_studies
/
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Aged
/
Humans
Idioma:
En
Revista:
Eur Heart J
Año:
2022
Tipo del documento:
Article
País de afiliación:
China