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Changes in Serum Neutralizing Antibodies Levels During Convalescence of COVID-19 Patients.
Chen, Qing-Qing; Gong, Lei; Wu, Xiao-Min; Feng, Ya-Ting; Luo, Wan-Rong; Zhou, Xue; Yuan, Yuan; Yu, Jun-Ling; He, Lan; Wang, Peng; Ge, Ying-Lu; Hou, Sai; Li, Wei-Wei; Sun, Yong; Wu, Jia-Bing; Su, Bin; Pan, Hai-Feng; He, Jun; Liu, Zhi-Rong.
Afiliación
  • Chen QQ; Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, China.
  • Gong L; Microbiological Laboratory, Public Health Research Institute of Anhui Province, Hefei, China.
  • Wu XM; Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, China.
  • Feng YT; Microbiological Laboratory, Public Health Research Institute of Anhui Province, Hefei, China.
  • Luo WR; Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, China.
  • Zhou X; Microbiological Laboratory, Public Health Research Institute of Anhui Province, Hefei, China.
  • Yuan Y; Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.
  • Yu JL; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China.
  • He L; Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, China.
  • Wang P; Microbiological Laboratory, Public Health Research Institute of Anhui Province, Hefei, China.
  • Ge YL; Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, China.
  • Hou S; Microbiological Laboratory, Public Health Research Institute of Anhui Province, Hefei, China.
  • Li WW; Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, China.
  • Sun Y; Microbiological Laboratory, Public Health Research Institute of Anhui Province, Hefei, China.
  • Wu JB; Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, China.
  • Su B; Microbiological Laboratory, Public Health Research Institute of Anhui Province, Hefei, China.
  • Pan HF; Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, China.
  • He J; Microbiological Laboratory, Public Health Research Institute of Anhui Province, Hefei, China.
  • Liu ZR; Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, China.
Front Med (Lausanne) ; 9: 829273, 2022.
Article en En | MEDLINE | ID: mdl-35223924
Detection of serum-specific SARS-CoV-2 antibody has become a complementary means for the identification of coronavirus disease 2019 (COVID-19). As we already know, the neutralizing antibody titers in patients with COVID-19 decrease during the course of time after convalescence, whereas the duration of antibody responses in the convalescent patients has not been defined clearly. In the current study, we collected 148 serum samples from 37 confirmed COVID-19 cases with different disease severities. The neutralizing antibodies (Nabs), IgM and IgG against COVID-19 were determined by CLIA Microparticle and microneutralization assay, respectively. The time duration of serum titers of SARS-CoV-2 antibodies were recorded. Our results indicate that IgG (94.44%) and Nabs (89.19%) can be detected at low levels within 190-266 days of disease onset. The findings can advance knowledge regarding the antibody detection results for COVID-19 patients and provide a method for evaluating the immune response after vaccination.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Med (Lausanne) Año: 2022 Tipo del documento: Article País de afiliación: China
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Med (Lausanne) Año: 2022 Tipo del documento: Article País de afiliación: China