Discovery of a large-scale, cell-state-responsive allosteric switch in the 7SK RNA using DANCE-MaP.

Olson, Samuel W; Turner, Anne-Marie W; Arney, J Winston; Saleem, Irfana; Weidmann, Chase A; Margolis, David M; Weeks, Kevin M; Mustoe, Anthony M

Olson, Samuel W; Turner, Anne-Marie W; Arney, J Winston; Saleem, Irfana; Weidmann, Chase A; Margolis, David M; Weeks, Kevin M; Mustoe, Anthony M.

Afiliación

Olson SW; Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599-3290, USA.
Turner AW; Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA; UNC HIV Cure Center, University of North Carolina, Chapel Hill, NC 27599, USA.
Arney JW; Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599-3290, USA.
Saleem I; Verna and Marrs McClean Department of Biochemistry and Molecular Biology, Therapeutic Innovation Center (THINC), Baylor College of Medicine, Houston, TX 77030, USA.
Weidmann CA; Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599-3290, USA.
Margolis DM; Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA; UNC HIV Cure Center, University of North Carolina, Chapel Hill, NC 27599, USA.
Weeks KM; Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599-3290, USA. Electronic address: weeks@unc.edu.
Mustoe AM; Verna and Marrs McClean Department of Biochemistry and Molecular Biology, Therapeutic Innovation Center (THINC), Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: anthony.mustoe@bcm.

Mol Cell ; 82(9): 1708-1723.e10, 2022 05 05.

Article en En | MEDLINE | ID: mdl-35320755

Asunto(s)

Factor B de Elongación Transcripcional Positiva; Proteínas de Unión al ARN; Sitios de Unión/genética; Células HeLa; Humanos; Factor B de Elongación Transcripcional Positiva/genética; ARN Nuclear Pequeño/genética; ARN no Traducido; Proteínas de Unión al ARN/genética

Palabras clave

DANCE-MaP; HIV; cancer; ensemble deconvolution; noncoding RNA; transcriptional regulation

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas de Unión al ARN / Factor B de Elongación Transcripcional Positiva Límite: Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

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