Magnolol prevented brain injury through the modulation of Nrf2-dependent oxidative stress and apoptosis in PLP-induced mouse model of multiple sclerosis.

Bibi, Tehmina; Khan, Adnan; Khan, Ashraf Ullah; Shal, Bushra; Ali, Hussain; Seo, Eun Kyoung; Khan, Salman

Bibi, Tehmina; Khan, Adnan; Khan, Ashraf Ullah; Shal, Bushra; Ali, Hussain; Seo, Eun Kyoung; Khan, Salman.

Afiliación

Bibi T; Pharmacological Sciences Research Lab, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
Khan A; Pharmacological Sciences Research Lab, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
Khan AU; Pharmacological Sciences Research Lab, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
Shal B; Faculty of Pharmaceutical Sciences, Abasyn University, Peshawar, Pakistan.
Ali H; Pharmacological Sciences Research Lab, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
Seo EK; Faculty of Health Sciences, IQRA University, Islamabad Campus, (Chak Shahzad), Islamabad, Pakistan.
Khan S; Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

Naunyn Schmiedebergs Arch Pharmacol ; 395(6): 717-733, 2022 06.

Article en En | MEDLINE | ID: mdl-35348816

Asunto(s)

Lesiones Encefálicas; Encefalomielitis Autoinmune Experimental; Esclerosis Múltiple; Animales; Antioxidantes/metabolismo; Antioxidantes/farmacología; Antioxidantes/uso terapéutico; Apoptosis; Compuestos de Bifenilo; Linfocitos T CD8-positivos/metabolismo; Linfocitos T CD8-positivos/patología; Caspasa 3/metabolismo; Modelos Animales de Enfermedad; Encefalomielitis Autoinmune Experimental/metabolismo; Encefalomielitis Autoinmune Experimental/patología; Femenino; Lignanos; Ratones; Simulación del Acoplamiento Molecular; Esclerosis Múltiple/tratamiento farmacológico; Factor 2 Relacionado con NF-E2/metabolismo; Estrés Oxidativo

Palabras clave

Experimental autoimmune encephalomyelitis; Magnolol; Multiple sclerosis; Nrf2; Oxidative stress

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Lesiones Encefálicas / Encefalomielitis Autoinmune Experimental / Esclerosis Múltiple Límite: Animals Idioma: En Revista: Naunyn Schmiedebergs Arch Pharmacol Año: 2022 Tipo del documento: Article País de afiliación: Pakistán

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